Maintenance of granuloma formation in pulmonary sarcoidosis by T lymphocytes within the lung

The New England Journal of Medicine
G W HunninghakeR G Crystal

Abstract

Pulmonary granulomata of sarcoidosis are composed primarily of mononuclear phagocytic cells that are probably derived from blood monocytes. To evaluate the concept that recruitment of blood monocytes to the sarcoid lung is mediated by chemoattractants produced by immune effector cells within the lung, we obtained mononuclear cells from lung and blood of six patients with active pulmonary sarcoidosis, six normal subjects, and six patients with active idiopathic pulmonary fibrosis and studied their ability to secrete a chemotactic factor for monocytes. Lung T lymphocytes from all sarcoidosis patients, but not from normal subjects or patients with idiopathic pulmonary fibrosis, spontaneously secreted such a mediator. Lung T lymphocytes from patients with sarcoidosis secreted more monocyte chemotactic factor than did blood T lymphocytes from the same patients. The accumulation of monocytes in the lung in patients with pulmonary sarcoidosis may be mediated by local production of monocyte chemotactic factor by lung T lymphocytes.

References

Sep 1, 1975·The American Journal of Medicine·D G JamesA Walker
May 1, 1977·Journal of Clinical Pathology·D N MitchellK F Hinson
Oct 1, 1978·Annals of Internal Medicine·S E WeinbergerR G Crystal
Apr 1, 1976·Annals of Internal Medicine·E G MaderazoA C DeGraff
Sep 1, 1977·The Journal of Clinical Investigation·J D FulmerR G Crystal
Jan 1, 1976·Annals of the New York Academy of Sciences·C B Carrington
Sep 14, 1975·The New England Journal of Medicine·A M Dannenberg
Jun 13, 1975·Annals of the New York Academy of Sciences·E J Goetzl
May 1, 1970·Acta Pathologica Japonica·M Takahashi
May 1, 1969·The Journal of Pathology·W G Spector, N Heesom
Mar 7, 1969·Science·P A WardJ R David

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Citations

Feb 1, 1988·Irish Journal of Medical Science·C M Burke, T M Healy
May 1, 1985·Clinical Reviews in Allergy·G W Hunninghake
Oct 2, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Alessandro AntonelliGiuliano Mariani
Oct 1, 1985·Seminars in Roentgenology·D G Freiman
Jan 1, 1990·Molecular Aspects of Medicine·A Shock, G J Laurent
Jun 1, 1996·Human Immunology·C VissingaP Concannon
Aug 20, 1981·The New England Journal of Medicine·G W Hunninghake, R G Crystal
Apr 24, 1997·The New England Journal of Medicine·L S NewmanL A Maier
Jan 1, 1989·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·G S Deepe, W E Bullock
Jun 1, 1992·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·O Evensen, B Bratberg
Jan 1, 1982·Thorax·B A Keogh, R G Crystal
Mar 1, 1983·Thorax·B H Davies
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·M BaltzanM G Cosio
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·M V HendricksW B Davis
Oct 6, 1999·American Journal of Respiratory and Critical Care Medicine·R A TahaQ A Hamid
Jan 1, 1989·The American Review of Respiratory Disease·D A WhiteS Gupta
May 1, 1993·The American Review of Respiratory Disease·T C Van MaarsseveenP J Van Diest
Nov 1, 1993·The American Review of Respiratory Disease·B A JohnsonB P Griffith
Aug 20, 2011·American Journal of Respiratory and Critical Care Medicine·Laura L KothPrescott G Woodruff
Dec 1, 1989·American Journal of Respiratory Cell and Molecular Biology·S SoneT Ogura
Sep 1, 1980·The Journal of Clinical Investigation·G W HunninghakeR G Crystal
Jan 1, 1985·The Journal of Clinical Investigation·A VenetR G Crystal
Mar 1, 1985·The Journal of Clinical Investigation·T OkabeB L Fanburg
Jan 1, 1993·The Journal of Clinical Investigation·J M ForresterB L Kotzin
Apr 1, 1984·Environmental Health Perspectives·W S Lynn

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