Maintenance of Immune Homeostasis through ILC/T Cell Interactions

Frontiers in Immunology
Nicole von BurgDaniela Finke

Abstract

Innate lymphoid cells (ILCs) have emerged as a new family of immune cells with crucial functions in innate and adaptive immunity. ILC subsets mirror the cytokine and transcriptional profile of CD4(+) T helper (TH) cell subsets. Hence, group 1 (ILC1), group 2 (ILC2), and group 3 (ILC3) ILCs can be distinguished by the production of TH1, TH2, and TH17-type cytokines, respectively. Cytokine release by ILCs not only shapes early innate immunity but can also orchestrate TH immune responses to microbial or allergen exposure. Recent studies have identified an unexpected effector function of ILCs as antigen presenting cells. Both ILC2s and ILC3s are able to process and present foreign antigens (Ags) via major histocompatibility complex class II, and to induce cognate CD4(+) T cell responses. In addition, Ag-stimulated T cells promote ILC activation and effector functions indicating a reciprocal interaction between the adaptive and innate immune system. A fundamental puzzle in ILC function is how ILC/T cell interactions promote host protection and prevent autoimmune diseases. Furthermore, the way in which microenvironmental and inflammatory signals determine the outcome of ILC/T cell immune responses in various tissues is not yet unders...Continue Reading

References

Apr 1, 1997·International Immunology·S AdachiS Nishikawa
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·N Noben-TrauthW E Paul
Feb 2, 1999·The Journal of Experimental Medicine·R Maldonado-LópezM Moser
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ralph Marvin Steinman, Michel C Nussenzweig
Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephen D HurstRobert L Coffman
Nov 15, 2003·Immunity·Jinfang ZhuWilliam E Paul
Mar 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Javier Cote-SierraWilliam E Paul
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alessandra ZingoniLewis L Lanier
Mar 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fabrina M C GaspalPeter J L Lane
Feb 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Takanori SoMichael Croft
May 17, 2006·The Journal of Experimental Medicine·David VoehringerRichard M Locksley
Jan 24, 2007·Immunity·Hergen Spits, Lewis L Lanier
Dec 31, 2008·The Journal of Experimental Medicine·Hiroaki TakatoriJohn J O'Shea
May 12, 2009·Immunological Reviews·Michael CroftPejman Soroosh
May 26, 2009·Immunity·Liang ZhouDan R Littman
May 26, 2009·Nature Immunology·Jacqueline G PerrigoueDavid Artis

❮ Previous
Next ❯

Citations

Jul 26, 2016·Frontiers in Immunology·Katharina Pallmer, Annette Oxenius
Sep 1, 2016·Mediators of Inflammation·Esmé van der GrachtMitchell Kronenberg
Jul 16, 2013·Current Opinion in Virology·Suzanne P M WeltenRamon Arens
Dec 10, 2016·Human Vaccines & Immunotherapeutics·Helmy Yusuf, Vicky Kett
Feb 4, 2016·Toxicologic Pathology·Tina Rubic-SchneiderMichael Kammüller
Mar 2, 2018·Annals of the New York Academy of Sciences·Martijn J Schuijs, Timotheus Y F Halim
Jun 22, 2016·Nature Immunology·Christoph S N Klose, David Artis
Jul 10, 2018·Journal of Leukocyte Biology·Kyle K PayneMasoud H Manjili
Dec 29, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tao LiuJoshua A Boyce
Jan 5, 2020·Nature Immunology·Gitalee SarkerAna I Domingos
Jul 28, 2017·The Journal of Experimental Medicine·Christian SchwartzPadraic G Fallon
Oct 31, 2017·Frontiers in Immunology·Alessandra Geremia, Carolina V Arancibia-Cárcamo
Aug 27, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aaron R VictorJianhua Yu
Jun 28, 2018·Seminars in Immunopathology·L MazzuranaJ Mjösberg
Aug 16, 2017·Expert Review of Clinical Immunology·Anna Głobińska, Marek L Kowalski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Lobular

Lobular carcinoma is an invasive type of breast cancer in which lobules, areas of the breast that produce milk, undergo malignant transformation. Here is the latest research.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.