Maintenance of mitochondrial DNA by the Caenorhabditis elegans ATR checkpoint protein ATL-1.

Genetics
Chihiro MoriAtsushi Higashitani

Abstract

Here we show that inactivation of the ATR-related kinase ATL-1 results in a significant reduction in mitochondrial DNA (mtDNA) copy numbers in Caenorhabditis elegans. Although ribonucleotide reductase (RNR) expression and the ATP/dATP ratio remained unaltered in atl-1 deletion mutants, inhibition of RNR by RNAi or hydroxyurea treatment caused further reductions in mtDNA copy number. These results suggest that ATL-1 functions to maintain mtDNA independently of RNR.

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Citations

Apr 17, 2010·Marine Biotechnology·Ikuo HironoTakashi Aoki
Oct 28, 2010·The Journal of Clinical Investigation·Natalia PapetaAli G Gharavi
Feb 7, 2012·Fish & Shellfish Immunology·Fernand F FagutaoIkuo Hirono
Jun 11, 2016·DNA Repair·Gururaj Rao KidiyoorMarco Foiani
May 3, 2013·PloS One·Juan A Subirana, Xavier Messeguer

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