Maintenance of real objects and their verbal designations in working memory

Neuroscience Letters
Stefan KaiserChristoph Stippich

Abstract

The present study investigated the neural correlates of working memory maintenance for real objects in contrast to their verbal designations. For this purpose we employed a delayed match-to-sample task using functional magnetic resonance imaging. The conjunction of load effects for objects and for words revealed a common bilateral network with main foci in the ventrolateral prefrontal cortex and the intraparietal sulcus. Load effect for objects in comparison to load effect for words revealed stronger activation of bilateral precuneus, which suggests the use of mental imagery of objects and object features. The opposite comparison load words versus load objects showed premotor and auditory areas to be activated in association with phonological rehearsal. The bilateral common activation indicates overlapping codes for real-world objects and their verbal designations. Importantly, there is also a dissociation between maintenance of words and objects, which indicates that phonological rehearsal and mental imagery are employed to different degrees.

References

Nov 1, 1986·The Quarterly Journal of Experimental Psychology. A, Human Experimental Psychology·A BaddeleyH Spinnler
Jan 1, 1981·Memory & Cognition·D J Schiano, M J Watkins
Jun 1, 1997·Cognitive Psychology·E E Smith, J Jonides
Sep 1, 1995·NeuroImage·P C FletcherR J Dolan
Aug 10, 2000·Experimental Brain Research·M D'EspositoB Rypma
Oct 5, 2001·Nature Reviews. Neuroscience·D A GusnardM E Raichle
Oct 16, 2002·Cerebral Cortex·Axel MecklingerD Yves Von Cramon
Dec 7, 2002·Cognitive, Affective & Behavioral Neuroscience·P RämäS M Courtney
Sep 27, 2003·Journal of Cognitive Neuroscience·T Jason Druzgal, Mark D'Esposito
Mar 26, 2004·Cognitive, Affective & Behavioral Neuroscience·Tor D Wager, Edward E Smith
Sep 28, 2004·Psychological Science·Brian GonsalvesKen A Paller
Apr 16, 2005·Current Opinion in Neurobiology·Charan Ranganath, Mark D'Esposito
Jul 19, 2005·Journal of Cognitive Neuroscience·J R BinderD A Medler
Jul 21, 2005·Memory & Cognition·Bradley R PostleSuzanne Corkin
Sep 13, 2005·NeuroImage·Boris SuchanGebhard Schmid
Jan 10, 2006·Brain : a Journal of Neurology·Andrea E Cavanna, Michael R Trimble
Sep 26, 2007·Journal of Cognitive Neuroscience·Christian J FiebachDavid Swinney

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Citations

Jan 6, 2011·Journal of Neurology·Michael KüperM Obermann
Apr 12, 2011·Brain : a Journal of Neurology·Aurélie KasMarie Sarazin
Nov 17, 2011·Ageing Research Reviews·Giuliana KlencklenAndré Dufour
Dec 7, 2010·Neurobiology of Aging·Martina PiefkeGereon R Fink
Jan 21, 2015·Journal of Cognitive Neuroscience·Annika C Linke, Rhodri Cusack
Apr 11, 2015·Behavioural Neurology·Silvia P CaminitiDaniela Perani
Jun 5, 2013·Journal of Neurodevelopmental Disorders·Evelien M BarendseAlbert P Aldenkamp

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