Maintenance of Remission with Etanercept-DMARD Combination Therapy Compared with DMARDs Alone in African and Middle Eastern Patients with Active Rheumatoid Arthritis

Rheumatology and Therapy
Hassan BassiouniKhalid Shirazy

Abstract

To compare etanercept (ETN) and placebo (PBO) for maintaining low disease activity (LDA) achieved with ETN in patients with rheumatoid arthritis (RA) from Africa and the Middle East. In this subset analysis of the Treat-to-Target trial (ClinicalTrials.gov identifier NCT01981473), 53 adult patients with moderate-to-severe RA nonresponsive to methotrexate were treated with 50 mg ETN/week for 24 weeks (Period 1). Patients achieving LDA were randomized to continue ETN treatment or switched to PBO for an additional 28 weeks (Period 2). The proportion of patients maintaining LDA or remission in each arm at the end of Period 2 was determined. Additional efficacy and patient-reported outcomes (PROs) were also evaluated. During Period 1, 51 patients achieved LDA according to the disease activity score-28 joints-erythrocyte sedimentation rate (DAS28-ESR LDA) and 30 achieved remission. At week 52, nine of 22 and eight of 29 in the ETN and PBO groups, respectively, remained in DAS28-ESR LDA without experiencing a flare. Additionally, six of 14 and five of 16 in the ETN and PBO groups, respectively, remained in remission. Among patients experiencing a flare during Period 2, 13 of 22 and 21 of 29 received ETN or PBO, respectively. The median...Continue Reading

References

Sep 12, 2008·Best Practice & Research. Clinical Rheumatology·Girish M Mody, Mario H Cardiel
Nov 13, 2013·La Clinica terapeutica·F ContiR Scrivo
Feb 27, 2014·Journal of Autoimmunity·Maria KourilovitchEsteban Ortiz-Prado
Mar 14, 2014·International Journal of Rheumatic Diseases·Hussein HalabiMaxime Dougados
Sep 30, 2014·The Cochrane Database of Systematic Reviews·Noortje van HerwaardenBart J F van den Bemt
Nov 6, 2014·The New England Journal of Medicine·Paul EmeryBonnie Vlahos
Apr 16, 2015·Annals of the Rheumatic Diseases·Ronald F van VollenhovenKarin Franck-Larsson
Nov 8, 2015·Arthritis Care & Research·Jasvinder A SinghTimothy McAlindon

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