Maintenance Therapy with 3-monthly Bacillus Calmette-Guérin for 3 Years is Not Superior to Standard Induction Therapy in High-risk Non-muscle-invasive Urothelial Bladder Carcinoma: Final Results of Randomised CUETO Study 98013

European Urology
Luis Martinez-PiñeiroJose Antonio Martinez-Piñeiro

Abstract

Bacillus Calmette-Guérin (BCG) maintenance therapy for 3 yr following BCG induction can reduce the progression of urothelial bladder carcinoma versus BCG induction alone, but is associated with high toxicity. To investigate whether a modified 3-yr BCG maintenance regimen following induction therapy is more effective than standard BCG induction therapy alone and exhibits a low toxicity profile. Patients from the outpatient clinics of the participating centres with high-risk non-muscle-invasive bladder carcinoma (NMIBC) were randomised between October 1999 and April 2007. Participants received BCG induction once-weekly for 6 wk (no maintenance arm) or BCG induction followed by one BCG instillation every 3 mo for 3 yr (maintenance arm). Primary endpoints were disease-free interval (DFI) and time to progression (TTP). Secondary endpoints included survival duration and toxicity. Differences between treatment arms were tested using Student's t test and χ(2) and log-rank tests. A total of 397 patients were randomised, 195 to the no-maintenance and 202 to the maintenance arm. A median time to recurrence was not reached in either treatment arm. DFI was similar between the arms (hazard ration [HR] 0.83; 95% CI 0.61-1.13; p=0.2) with dise...Continue Reading

References

Jul 11, 2003·The Journal of Urology·Marc-Oliver GrimmThomas Alexander Vogeli
Jul 6, 2013·European Urology·Marko BabjukUNKNOWN European Association of Urology

❮ Previous
Next ❯

Citations

Jun 22, 2016·European Urology·Marko BabjukRichard Zigeuner
Jul 4, 2018·Minerva urologica e nefrologica = The Italian journal of urology and nephrology·Rodolfo HurleGiovanni Lughezzani
Nov 14, 2018·Minerva urologica e nefrologica = The Italian journal of urology and nephrology·Marco MoschiniUNKNOWN European Association of Urology - European Society of Resident Urologists (EAU-ESRU)
Mar 25, 2019·Cancer Medicine·Hongwei SuChong Li
Aug 16, 2017·Journal for Immunotherapy of Cancer·Ashish M KamatJonathan E Rosenberg
Oct 17, 2018·Nature Reviews. Urology·Brian Jordan, Joshua J Meeks
Dec 3, 2020·ClinicoEconomics and Outcomes Research : CEOR·Lauren J LeeIra A Jacobs
Nov 13, 2021·Future Oncology·Samantha R Unsworth-WhiteRichard T Bryan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

© 2021 Meta ULC. All rights reserved