Maintenance tocolysis with nifedipine in threatened preterm labour: 2-year follow up of the offspring in the APOSTEL II trial

BJOG : an International Journal of Obstetrics and Gynaecology
Eog van VlietMartijn A Oudijk

Abstract

To evaluate long-term effects of maintenance tocolysis with nifedipine on neurodevelopmental outcome of the infant. Follow up of infants of women who participated in a multicentre randomised controlled trial on maintenance tocolysis with nifedipine versus placebo. Two years after the APOSTEL II trial on maintenance tocolysis with nifedipine versus placebo, we asked participants to complete the Ages and Stages Questionnaire. Infant development was measured in five domains. Developmental delay was defined as a score of ≤1 SD in one or more developmental domains. We performed exploratory subgroup analysis in women with preterm prolonged rupture of the membranes, and in women with a cervical length <10 mm at study entry. Of the 276 women eligible for follow up, 135 (52.5%) returned the questionnaire, encompassing data of 170 infants. At 2 years of age, infants of women with nifedipine maintenance tocolysis compared with placebo had a higher overall incidence of fine motor problems (22.2 versus 7.6%, OR 3.43, 95% CI 1.29-9.14, P = 0.01), and a lower incidence of poor problem-solving (21.1 versus 29.1%, OR 0.27, 95% CI 0.08-0.95, P = 0.04). This follow-up study revealed no clear benefit of nifedipine maintenance tocolysis at 2 years ...Continue Reading

References

Dec 1, 1989·American Journal of Obstetrics and Gynecology·J E FergusonT Blaschke
Aug 1, 1997·Obstetrics and Gynecology·D N PapatsonisG A Dekker
May 1, 2001·Journal of Paediatrics and Child Health·C Y SkellernM J O'Callaghan
Nov 26, 2002·Journal of the Society for Gynecologic Investigation·Richard BergerArne Jensen
May 24, 2003·BJOG : an International Journal of Obstetrics and Gynaecology·Marc J N C Keirse
Feb 21, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·B A HoutzagerA G van Wassenaer
Mar 28, 2006·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S GucluA A Baschat
May 18, 2006·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Srinivas BolisettyKei Lui
Feb 15, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·A-L SilberschmidtU von Mandach
May 30, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Roel de HeusGerard H A Visser
Aug 26, 2009·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M M De S LimaA F Moron
Sep 10, 2009·BMC Pregnancy and Childbirth·Carolien RoosFred K Lotgering
May 5, 2012·Journal of Perinatology : Official Journal of the California Perinatal Association·A S SoraishamR Sauve
Jun 13, 2012·Pediatrics·Marie-Noëlle SimardJulie Gosselin
Jan 3, 2013·JAMA : the Journal of the American Medical Association·Carolien RoosUNKNOWN APOSTEL-II Study Group
Dec 24, 2013·The Journal of Pediatrics·Karli TreyvaudPeter J Anderson
Mar 15, 2014·Reproductive Health·Hannah BlencoweUNKNOWN Born Too Soon Preterm Birth Action Group
Sep 23, 2014·The Cerebellum·Marie Brossard-RacineCatherine Limperopoulos

❮ Previous
Next ❯

Citations

May 21, 2016·BJOG : an International Journal of Obstetrics and Gynaecology·C V Ananth, J A Lavery
Dec 25, 2015·Science Translational Medicine·Roger Smith
Mar 4, 2020·BJOG : an International Journal of Obstetrics and Gynaecology·Tms van WindenM A Oudijk
Dec 2, 2017·Seminars in Perinatology·Sarah R MurrayJane E Norman
Sep 26, 2017·Seminars in Perinatology·Isabelle DehaeneUNKNOWN from the International Spontaneous Preterm birth Young Investigators group (I-SPY)

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.