PMID: 8584586Jan 1, 1995Paper

Maintenance treatment of schizophrenia: a review of dose reduction and family treatment strategies

The Psychiatric Quarterly
N R SchoolerS M Matthews

Abstract

Maintenance treatment in schizophrenia requires the integration of both medication and psychosocial treatment interventions for maximum effect. We review the recent evidence for strategies drawn from both domains. For the use of anti-psychotic medication we focus on studies of dose reduction using two strategies that differ in assumptions regarding the action of medication. They are: continuous low-dose and targeted, early intervention or intermittent treatment. For psychosocial interventions we focus on studies of family treatment. Regarding dose reduction, we conclude that both strategies are feasible but the targeted strategy incurs higher relapse and rehospitalization rates. Regarding family treatment, we conclude that family treatment provides benefits beyond other psychosocial interventions or usual care, but that there is no evidence for differences in efficacy among family treatments.

References

Dec 1, 1975·The American Journal of Psychiatry·J M Davis
Oct 1, 1978·Archives of General Psychiatry·M J GoldsteinM R Steinberg
Aug 1, 1976·The British Journal of Psychiatry : the Journal of Mental Science·C E Vaughn, J P Leff
Apr 1, 1991·Archives of General Psychiatry·M I HerzJ Vana
Jan 1, 1991·Schizophrenia Bulletin·N R Schooler
Sep 11, 1990·The American Journal of Psychiatry·W T CarpenterR W Buchanan
Jan 1, 1990·New Directions for Mental Health Services·S M Brady, E Carmen
Oct 1, 1990·The British Journal of Psychiatry : the Journal of Mental Science·J LeffC Vaughn
Jan 1, 1990·Journal of Affective Disorders·J F ClarkinV Lestelle
May 1, 1989·The British Journal of Psychiatry : the Journal of Mental Science·N TarrierH Freeman
Jan 1, 1989·The British Journal of Psychiatry : the Journal of Mental Science·J LeffC Vaughn
Oct 1, 1988·The British Journal of Psychiatry : the Journal of Mental Science·N TarrierH Freeman
Mar 1, 1988·Archives of General Psychiatry·G L HaasV Lestelle
Jun 1, 1987·Archives of General Psychiatry·S R MarderP R May
Jun 1, 1985·The British Journal of Psychiatry : the Journal of Mental Science·J LeffD Sturgeon
Sep 1, 1972·The British Journal of Psychiatry : the Journal of Mental Science·G W BrownJ K Wing
Jun 17, 1982·The New England Journal of Medicine·I R FalloonA M Gilderman
Aug 1, 1983·Archives of General Psychiatry·J M KaneJ Ramos-Lorenzi
Nov 1, 1984·Archives of General Psychiatry·S R MarderP R May
Aug 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·J LeffD Sturgeon
Apr 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·E T RandolphR P Liberman
Jan 1, 1993·Schizophrenia Bulletin·J M Kane, S R Marder
Jan 1, 1993·Schizophrenia Bulletin·A S Bellack, K T Mueser
May 29, 2000·The American Journal of Orthopsychiatry·W R McFarlaneB Link

❮ Previous
Next ❯

Citations

Feb 7, 1998·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J M KaneN R Schooler
Aug 21, 2004·International Journal of Mental Health Nursing·Berno van MeijelMaria H F Grypdonck
Aug 26, 2014·The International Journal of Social Psychiatry·Manolis MentisEuthymios Dardiotis
Jul 1, 2020·The International Journal of Social Psychiatry·Antonio VentriglioAntonello Bellomo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.