PMID: 9445036Jan 28, 1998Paper

Major and minor receptor group human rhinoviruses penetrate from endosomes by different mechanisms

Journal of Virology
D SchoberR Fuchs

Abstract

Intercellular adhesion molecule 1 and the low-density lipoprotein receptor are used for cell entry by major and minor receptor group human rhinoviruses (HRVs), respectively. Whereas minor-group viruses, exemplified by HRV2, transfer their genomic RNA to the cytoplasm through a pore in the endosomal membrane (E. Prchla, C. Plank, E. Wagner, D. Blaas, and R. Fuchs, J. Cell Biol. 131:111-123, 1995), the mechanism of in vivo uncoating of major-group HRVs has not been elucidated so far. Using free-flow electrophoresis, we performed a comparative analysis of cell entry by HRV2 and the major group rhinovirus HRV14. Here we demonstrate that this technique allows the separation of free viral particles from those associated with early endosomes, late endosomes, and plasma membranes. Upon free-flow electrophoretic separation of microsomes, HRV14 was recovered from endosomes under conditions which prevent uncoating, whereas the proportion of free viral particles increased with time under conditions which promote uncoating. The remaining virus eluted within numerous fractions corresponding to membraneous material, with no clear endosomal peaks being discernible. This suggests that uncoating of HRV14 results in lysis of the endosomal membran...Continue Reading

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Citations

Mar 3, 2004·Journal of Virology·Günther BaravalleRenate Fuchs
Jun 18, 2010·Journal of Virology·Jani SeitsonenSarah J Butcher
Dec 14, 2011·Molecular Biology of the Cell·Nina RintanenVarpu Marjomäki
Dec 8, 2017·Scientific Reports·Antonio Real-HohnAndre Marco Oliveira Gomes
Jul 19, 2002·Human Mutation·Ludovic VillégerMathilde Varret
Jan 19, 2002·Journal of Virology·Varpu MarjomäkiJyrki Heino
Jun 16, 2005·Journal of Virology·Stephen BerrymanTerry Jackson
Sep 10, 2004·Molecular Biology of the Cell·Vilja PietiäinenTimo Hyypiä
Jun 16, 2005·Journal of Virology·Vivian O'DonnellBarry Baxt
Feb 8, 2008·Journal of Virology·Matthew P DavisTobias J Tuthill
Jan 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christine LauChung-Wai Chow
Jan 23, 2009·Journal of Virology·Marianne Brabec-ZarubaRenate Fuchs
Sep 8, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Catharina SchraufJohannes Stöckl
Dec 12, 2012·Advances in Virology·Renate Fuchs, Dieter Blaas
Sep 18, 2015·Microbiology and Molecular Biology Reviews : MMBR·Jan P Buchmann, Edward C Holmes
Apr 15, 2003·Journal of Virology·Luc SnyersDieter Blaas
Jul 16, 2010·Reviews in Medical Virology·Renate Fuchs, Dieter Blaas
Jun 24, 2016·Journal of Virology·Rick ConzemiusRenate Fuchs
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Sep 2, 2020·International Journal of Pharmaceutics·Yasmin Abo-ZeidGary R McLean

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