Abstract
Recent cell biologic studies have emphasized the importance of the basement membrane (BM) and its molecular components in angiogenesis. We immunostained 60 angioproliferative lesions (angiosarcoma, sclerosing hemangioma of skin, pyogenic granuloma, capillary hemangioma, lymphangioma, glomangioma and granulation tissue) and 23 cases of Kaposi's sarcoma (KS) for the major macromolecular components laminin, collagen type IV, fibronectin and heparan sulfate proteoglycan (HSPG). Normal structures served as aggregate controls in each group, and semiquantitative scoring reflected the degree of consistency of staining about blood and lymphatic endothelium and vascular sheath (pericyte/smooth muscle) within and peripheral to each lesion. Benign and reactive vasoproliferations consistently maintained immunoreactivity for each BM component around endothelium and sheath components of blood vessels. Angiosarcoma showed from 20 to more than 60% less consistent immunoreactivity by comparison, although the score variances were greater than for non-malignant lesions. Staining about blood vessel endothelium was both strong and consistent among histologic stages in KS with the exception of HSPG, which was weakly immunoreactive in all stages. Mark...Continue Reading
References
Nov 1, 1979·Archives of Dermatological Research·W SterryE Bodeux
Jan 1, 1992·Critical Reviews in Biochemistry and Molecular Biology·M Paulsson
Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·S HaraidaE Schleicher
Jan 1, 1992·The Journal of Cell Biology·P Kallunki, K Tryggvason
Oct 1, 1991·Pathology·T V RileyC L Golledge
May 1, 1991·Pathology, Research and Practice·A NerlichE Schleicher
Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·M DictorL Flamholc
Oct 1, 1990·American Journal of Respiratory Cell and Molecular Biology·A E Chung, M E Durkin
Jul 1, 1990·The Journal of Pathology·E A SankeyA P Dhillon
Jun 15, 1989·International Journal of Cancer. Journal International Du Cancer·S WernerW K Roth
Sep 8, 1989·Cell·D E Ingber, J Folkman
Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·M Dictor
Jul 1, 1986·Journal of Clinical Pathology·R R JonesE W Jones
Nov 1, 1986·Histopathology·M LeaderK Henry
Sep 1, 1988·Journal of Oral Pathology·H NadimiP D Toto
Jun 1, 1988·The American Journal of Surgical Pathology·H Autio-HarmainenL Risteli
Dec 1, 1985·Pathology, Research and Practice·A BendelacJ Thivolet
Oct 1, 1983·The American Journal of Surgical Pathology·S H BarskyL A Liotta
Aug 1, 1981·American Journal of Clinical Pathology·L G GuardaJ L Smith