Major clinical research advances in gynecologic cancer in 2017

Journal of Gynecologic Oncology
Dong Hoon SuhJae Weon Kim

Abstract

In 2017, 10 topics were selected as major clinical research advances in gynecologic oncology. For cervical cancer, efficacy and safety analysis results of a 9-valent human papillomavirus (HPV) vaccine and long-term impact of reduced dose of quadrivalent vaccine were updated. Brief introduction of KEYNOTE trials of pembrolizumab, a monoclonal antibody that blocks the interaction between programmed death (PD)-1 and its ligands, PD-L1 and PD-L2, followed. Tailored surveillance programs for gynecologic cancer related with Lynch syndrome and update on sentinel lymph node mapping were reviewed for uterine corpus cancer. For ovarian cancer, 5 topics were selected including poly(ADP-ribose) polymerases inhibitors and immunotherapy. The other potential practice changers covered in this review were lymphadenectomy in advanced disease, secondary cytoreductive surgery in recurrent disease, weekly dose-dense regimen for first-line chemotherapy, incorporation of bevacizumab maintenance in platinum-sensitive recurrent disease, and effect of platinum-free interval prolongation. Conflicting opinions of academic societies on periodic pelvic examination were introduced in conjunction with relevant literature review. For the field of radiation onc...Continue Reading

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Citations

Dec 26, 2018·Clinical and Experimental Immunology·A PawłowskaI Wertel
Feb 23, 2019·International Journal of Molecular Sciences·Marco GreppiEmanuela Marcenaro
Nov 21, 2018·Targeted Oncology·Young-A Heo, Sohita Dhillon
Feb 26, 2019·Journal of Gynecologic Oncology·Miseon KimJae Weon Kim
Oct 30, 2020·Cancer Management and Research·Anna PawłowskaIwona Wertel
Nov 6, 2020·Journal of Ovarian Research·Mohammad Hossein PourhanifehHamed Mirzaei

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Methods Mentioned

BETA
contraception
biopsy

Clinical Trials Mentioned

NCT02054806
NCT02628067

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