Major depression and dimensional representations of DSM-IV personality disorders: a population-based twin study.

Psychological Medicine
T Reichborn-KjennerudK S Kendler

Abstract

Major depressive disorder (MDD) co-occurs frequently with personality disorders (PDs). The extent to which this results from shared genetic or environmental risk factors remains uncertain. Young adult twins (n=2801) from the population-based Norwegian Institute of Public Health Twin Panel were assessed at personal interview for DSM-IV lifetime MDD and the 10 Axis II PDs. The relationship between MDD and dimensional representations of all PDs was explored by stepwise logistic regression. Multivariate Cholesky twin models were fitted using the Mx program, and genetic and environmental correlations were estimated. Dimensional representations of borderline (BPD), avoidant (AVPD) and paranoid personality disorder (PPD) were independently and significantly associated with increased risk for MDD. Multivariate twin modeling indicated that one latent factor accounted for the genetic covariance between MDD and the three PDs. The genetic correlations between MDD and dimensional representations of BPD, AVPD and PPD were +0.56, +0.22 and +0.40 respectively. No sex differences or shared environmental effects were found. The structure of the individual-specific environmental factors influencing MDD and the three PDs were similar to the geneti...Continue Reading

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Citations

Nov 29, 2012·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Thomas S NilsenJennifer R Harris
Apr 24, 2012·Journal of Personality Assessment·Donald R LynamThomas A Widiger
Jun 13, 2012·Journal of Personality Disorders·Ragnhild E ØrstavikTed Reichborn-Kjennerud
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May 6, 2014·Social Psychiatry and Psychiatric Epidemiology·Kristian Amundsen ØstbyTed Reichborn-Kjennerud
Aug 4, 2012·BMC Geriatrics·Nahathai WongpakaranRobert van Reekum
Jan 7, 2015·Journal of Personality Disorders·Johanne Smith-NielsenMette Skovgaard Væver
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May 21, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sylvie Hélène Marie Jeanne PiacentiniMassimo Leone

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