Major depression and generalized anxiety disorder among human T-lymphotropic virus types I- and II-infected former blood donors.

Transfusion
Anne M GuiltinanHTLV Outcomes Study (HOST)

Abstract

Other studies have reported high rates of depression and anxiety among human T-lymphotropic virus Type I (HTLV-I)-infected subjects and have even suggested that HTLV-I causes psychiatric disease. We interviewed HTLV-I, HTLV-II, and demographically similar HTLV-seronegative blood donors with the Mini-International Neuropsychiatric Interview. Prevalences of major depression and generalized anxiety disorder in each group were calculated and compared to published US population data. Adjusted odds ratios (aOR) and 95% confidence intervals (CIs) controlling for educational achievement, alcohol intake, and self-reported health status were calculated with multivariate logistic regression. Major depression was diagnosed in five (5.4%) of 93 HTLV-I-positive subjects (aOR, 2.19; 95% CI, 0.63-7.55) and 17 (6.6%) of 256 HTLV-II-positive subjects (aOR, 1.61; 95% CI, 0.66-3.927), compared to 12 (2.1%) of 585 HTLV-seronegative blood donors. The prevalence of major depression among infected subjects was comparable to the 6.7% prevalence in the US general population. Generalized anxiety disorder was diagnosed in five (5.4%) HTLV-I-positive subjects (OR, 2.32; 95% CI, 0.74-7.26) and 12 (4.7%) HTLV-II-positive subjects (OR, 1.65; 95% CI, 0.68-4.01...Continue Reading

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Citations

Feb 1, 2015·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Ney Boa-SorteBernardo Galvão-Castro
Aug 19, 2016·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Farnaz VahidniaBrian Custer
Jul 5, 2018·Revista Da Sociedade Brasileira De Medicina Tropical·Pedro Augusto Sampaio Rocha-Filho, Liliana Raulino Goncalves
May 29, 2015·PloS One·Glória O OrgeLucas C Quarantini
Nov 13, 2018·PLoS Neglected Tropical Diseases·Carolina RosadasMarzia Puccioni-Sohler
Apr 25, 2020·Frontiers in Microbiology·Kazuo ItabashiToshiki Watanabe

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