Major depression, antidepressant use, and male and female fertility

Fertility and Sterility
Emily A Evans-HoekerReproductive Medicine Network

Abstract

To determine if maternal major depression (MD), antidepressant use, or paternal MD are associated with pregnancy outcomes after non-IVF fertility treatments. Cohort study. Clinics. Participants in two randomized trials: PPCOS II (clomiphene citrate versus letrozole for polycystic ovary syndrome), and AMIGOS (gonadotropins versus clomiphene citrate versus letrozole for unexplained infertility). Female and male partners completed the Patient Health Questionnaire (PHQ-9). Female medication use was collected. PHQ-9 score ≥10 was used to define currently active MD. Primary outcome: live birth. pregnancy, first-trimester miscarriage. Poisson regression models were used to determine relative risks after adjusting for age, race, income, months trying to conceive, smoking, and study (PPCOS II versus AMIGOS). Data for 1,650 women and 1,608 men were included. Among women not using an antidepressant, the presence of currently active MD was not associated with poorer fertility outcomes (live birth, miscarriage), but rather was associated with a slightly increased likelihood of pregnancy. Maternal antidepressant use (n = 90) was associated with increased risk of miscarriage, and male partners with currently active MD were less likely to achi...Continue Reading

Associated Clinical Trials

Jul 21, 2008·Heping Zhang, Heping Zhang

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Citations

Jul 7, 2019·Pharmacotherapy·Pingsheng WuKatherine E Hartmann
Jul 1, 2020·The Journal of International Medical Research·Filip SzkodziakPiotr Szkodziak
Jan 25, 2019·Harvard Review of Psychiatry·Christie SylvesterPriya Gopalan
Jul 1, 2020·Obstetrical & Gynecological Survey·Elizabeth P HowellKelly S Acharya
Jan 6, 2021·Journal of Assisted Reproduction and Genetics·Angela K LawsonMary Ellen Pavone
Jan 20, 2021·Open Biology·Shubhadeep RoychoudhuryPetr Slama
Jan 14, 2021·Middle East Fertility Society Journal·Indu SharmaSubhas Chandra Saha
Dec 19, 2020·International Journal of Environmental Research and Public Health·Shubhadeep RoychoudhuryPetr Slama
Jan 22, 2021·The World Journal of Men's Health·Caterina MontagnoliGiovanni Zanconato
Feb 8, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·G M Hviid MallingL Schmidt
May 30, 2020·Reproductive Biomedicine Online·Rong LiJie Qiao
May 11, 2021·Fertility and Sterility·Jennifer J YlandLauren A Wise
Sep 6, 2020·Journal of Psychosomatic Research·Dexiu XingTingting Wang
Sep 7, 2021·Human Reproduction·Rita RahbanSerge Nef
Jan 14, 2022·Human Reproduction·Jennifer J YlandIoannis Ch Paschalidis

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