Major differences exist in frequencies of virulence factors and multidrug resistance between community and nosocomial Escherichia coli bloodstream isolates.

Journal of Clinical Microbiology
Niamh M CookeThomas R Rogers

Abstract

Escherichia coli is a major cause of bloodstream infections and death due to sepsis. It is the most frequent Gram-negative bacterial pathogen recovered from cultures of blood from both community-acquired and nosocomial cases. We set out to determine the relationships between E. coli virulence factors (VFs), phylogenetic groups, and antibiotic resistance and whether bacteremia cases had a community, health care-associated. or nosocomial origin. Isolates from consecutive episodes of E. coli bacteremia in 303 patients presenting to a university hospital were screened for their VFs, phylogenetic group, and antibiotic resistance. The majority of VFs present in the collection were equally distributed between antibiotic-susceptible and multiple-drug-resistant (MDR) isolates, but the overall VF score was higher for isolates of community and health care-associated origin than those of nosocomial origin (P = 0.0002 and P = 0.0172, respectively); the papA, papG allele II, hlyA, and hek VFs were more prevalent in this cohort. Most isolates belonged to phylogenetic group B2, which harbored a greater proportion of antibiotic-susceptible isolates than MDR isolates (P = 0.04). The community, health care-associated, or nosocomial origin of E. c...Continue Reading

References

Sep 30, 2000·Applied and Environmental Microbiology·O ClermontE Bingen
May 31, 2002·Journal of Clinical Microbiology·F Javier Pérez-Pérez, Nancy D Hanson
Sep 22, 2006·Enfermedades infecciosas y microbiología clínica·Sara M Soto
Sep 22, 2006·Enfermedades infecciosas y microbiología clínica·Eva MorenoAntonia Andreu
Mar 3, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·N GrudeB-E Kristiansen
May 15, 2007·The Journal of Antimicrobial Chemotherapy·P L HoUNKNOWN COMBAT study group
Jul 10, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F JauréguyO Lortholary
Jul 31, 2007·The Journal of Antimicrobial Chemotherapy·Stéphane CorvecNathalie Caroff
Oct 24, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·V HoudouinE Bingen
Feb 6, 2008·The Journal of Antimicrobial Chemotherapy·Hedi MammeriPatrice Nordmann
Mar 13, 2008·The Journal of Antimicrobial Chemotherapy·Olivier ClermontGuillaume Arlet
May 17, 2008·Experimental and Molecular Pathology·Travis J WilesMatthew A Mulvey
Jun 3, 2008·Diagnostic Microbiology and Infectious Disease·George G ZhanelUNKNOWN Canadian Antimicrobial Resistance Alliance
Oct 18, 2008·Journal of Medical Microbiology·Matija RijavecDarja Zgur-Bertok
Oct 24, 2008·Postgraduate Medicine·Daniel F SahmAlan T Evangelista
Dec 2, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F BertM-H Nicolas-Chanoine
Dec 2, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·K B LauplandJ D D Pitout
May 14, 2009·The Journal of Antimicrobial Chemotherapy·Majdi N Al-HasanLarry M Baddour

❮ Previous
Next ❯

Citations

Apr 22, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·N L RamosA Brauner
Aug 24, 2012·Journal of Clinical Microbiology·Nubia L RamosAnnelie Brauner
Oct 8, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·F FreitasL Peixe
Oct 11, 2015·Folia Microbiologica·Codruţa-Romaniţa UseinMonica Strãuţ
Aug 24, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·V PascualE Calbo
May 21, 2017·Biomédica : revista del Instituto Nacional de Salud·Yasmin VarelaMaría Araque
Sep 19, 2019·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Marion HutinelCarl-Fredrik Flach
Dec 8, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·N KaramiI Adlerberth

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.