PMID: 3322066Sep 1, 1987Paper

Major histocompatibility antigens on trophoblast and their regulation: implications in the maternal-fetal relationship

American Journal of Reproductive Immunology and Microbiology : AJRIM
J R HeadF A Zuckermann

Abstract

Recent technological advances have provided methods of detecting antigens encoded by the major histocompatibility complex with greater precision, allowing the expression of such antigens on the components of the placenta to be clarified. Of specific interest is the expression of these antigens on trophoblast cells, the fetal-derived epithelial cells that confront maternal blood and tissues at the maternal-fetal interface. It is now clear that the different trophoblast subpopulations differentially express class I antigens, although none appear to express class II antigens. Class I antigens can be induced by exposure to interferons on some populations but apparently not others, suggesting that the regulation of their expression differs for subpopulations of trophoblast cells, depending on gestational stage and location. This restricted expression has important implications for maternal-fetal immune interactions during the different phases of pregnancy and perhaps also bears on physiological functions of the feto-placental unit, such as growth and differentiation.

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Citations

Jun 1, 1990·American Journal of Reproductive Immunology : AJRI·J S Hunt, B L Hsi
Jan 1, 1990·American Journal of Reproductive Immunology : AJRI·M SaitoT J Gill
Nov 15, 1989·International Journal of Cancer. Journal International Du Cancer·A VerstuyfM Vandeputte
Jul 1, 1990·American Journal of Reproductive Immunology : AJRI·S Ellis
Sep 12, 2000·Journal of Hematotherapy & Stem Cell Research·T AboussaouiraH Gérard
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew M Seavey, Tim R Mosmann
Aug 1, 1992·American Journal of Reproductive Immunology : AJRI·A VerstuyfM Vandeputte
May 1, 1988·American Journal of Reproductive Immunology and Microbiology : AJRIM·D J Anderson, J A Hill
Jan 1, 1992·Archives of Gynecology and Obstetrics·P Mallmann, K Diedrich
Jul 1, 1989·American Journal of Reproductive Immunology : AJRI·J R Head
Jan 1, 1995·American Journal of Reproductive Immunology : AJRI·W A BennettB D Cowan
Mar 1, 1992·Journal of Reproductive Immunology·I Athanassakis-VassiliadisJ Papamatheakis

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