PMID: 9548077Apr 21, 1998Paper

Major histocompatibility class II genes polymorphism in insulin dependent diabetes mellitus with or without associated thyroid autoimmunity

Human Immunology
I Djilali-SaiahS Caillat-Zucman

Abstract

Insulin dependent diabetes mellitus (IDDM) is sometimes associated with extrapancreatic organ-specific autoimmune diseases, but whether this phenotype results from a peculiar genetic profile is still unclear. The allelic distribution of the major histocompatibility complex (MHC) class II genes (HLA-DRB1, DQA1, DQB1 and TAP) was analysed in 143 patients with IDDM alone by comparison with 82 IDDM patients with autoimmune thyroid disease (IDDM/AITD). The frequency of the DQB1*0301 IDDM-protective phenotype seemed to be lower in IDDM than in IDDM/AITD patients (16.8% vs 30.5% respectively, p = 0.02). By contrast, the frequency of the DRB1*04-DQB1*0302 IDDM-predisposing phenotype was higher in IDDM than in IDDM/AITD patients (91.3% vs 76.1% of DR4-positive patients respectively, p = 0.007), but these differences were not significant after correcting the p values, except in the case of the DRB1*0405-DQB1*0302 combination (21.3% vs 2.4% of DR4-positive patients, Pc = 0.05). Furthermore, all differences disappeared when patients were matched for age at IDDM-onset. Our data do not long give support for a particular role of MHC class II genes in favouring the occurrence of thyroid autoimmunity in IDDM patients, but rather suggest that so...Continue Reading

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Citations

Jun 29, 2004·Human Immunology·Lara LevinYaron Tomer
May 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L J FanningF Shanahan
Mar 15, 2005·Journal of Autoimmune Diseases·Dimitry A Chistiakov
Sep 2, 2003·Journal of Pediatric Endocrinology & Metabolism : JPEM·Z SumníkO Cinek

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