PMID: 8610164Apr 2, 1996Paper

Major histocompatibility complex class I molecule serves as a ligand for presentation of the superantigen staphylococcal enterotoxin B to T cells

Proceedings of the National Academy of Sciences of the United States of America
A C HäffnerC A Elmets

Abstract

Superantigens, such as staphylococcal enterotoxin B (SEB), elicit a strong proliferative response in T cells when presented in the context of major histocompatibility complex (MHC) class II molecules. We observed a similar T-cell response, when MHC class II-negative epidermal cell lines were employed as antigen-presenting cells. Immunoprecipitation studies indicated that the ligand to which SEB bound had a molecular mass of 46 kDa. Radiolabeled SEB could be immunoprecipitated from isolated membrane proteins on the SCC13 epidermal cell line with a monoclonal antibody directed against the MHC class I molecule, and transfection of the K-562 cell line with MHC class I molecules showed a 75% increased SEB-binding capacity compared with the nontransfected MHC class I- and class II-negative counterpart. In functional studies, antibodies to the MHC class I molecule inhibited T-cell proliferation by at least 50%. From these studies, we conclude that MHC class I molecules on malignant squamous cell carcinomas serve as ligands for SEB, which, given the appropriate costimulatory signals, is sufficient to allow for superantigen-induced T-cell proliferation.

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Citations

Mar 29, 2002·Current Allergy and Asthma Reports·Claus BachertPaul van Cauwenberge
May 25, 2002·Allergy·C BachertP van Cauwenberge
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·R A HellerR W Davis
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·G StuhlerS F Schlossman
Jan 7, 2010·BMC Cancer·Sitti Rahma Abdul HafidKalanithi Nesaretnam
Sep 2, 2004·Respiratory Medicine·Gernot RohdeClaus Bachert
Nov 23, 2006·Ultrasound in Medicine & Biology·Michael L Oelze, James F Zachary
Mar 12, 2021·The Journal of Clinical Investigation·Rebecca A PorrittMoshe Arditi

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