PMID: 9159152May 27, 1997Paper

Major histocompatibility complex gene mapping in the amphibian Xenopus implies a primordial organization

Proceedings of the National Academy of Sciences of the United States of America
M NonakaM Flajnik

Abstract

One of the most provocative recent discoveries in immunology was the description of a genetic linkage in the major histocompatibility complex (MHC) between structurally unrelated genes whose products are involved in processing and presentation of antigens for recognition by T lymphocytes. Genes encoding MHC class I molecules, which bind and present at the cell surface proteolytic fragments of cytosolic proteins, are linked to nonhomologous genes whose products are involved in the production and subsequent transfer of such fragments into the endoplasmic reticulum. In mammals, the class I presentation and processing genes are found in different regions of the MHC. To examine the evolutionary origins of this genetic association, linkage studies were carried out with Xenopus, an amphibian last sharing an ancestor with mammals over 350 million years ago. In contrast to mammals, the single copy Xenopus class I gene is located between the class II and III regions, speculated to be in close linkage with the processing and transport genes. In addition to suggesting a primordial organization of genes involved in class I antigen presentation, these linkage studies further provide insight into the origins of the MHC class III region and th...Continue Reading

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Citations

Dec 18, 2004·Immunogenetics·James KelleyJohn Trowsdale
Dec 13, 2000·Developmental and Comparative Immunology·M CourtetL Du Pasquier
Jan 13, 2001·Current Opinion in Immunology·M Nonaka
May 5, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·L Du Pasquier
Feb 21, 2008·Proceedings. Biological Sciences·Jandouwe Villinger, Bruce Waldman
Jan 23, 1999·Immunological Reviews·J O Sunyer, J D Lambris
Jan 23, 1999·Immunological Reviews·M NonakaA Shima
Jan 23, 1999·Immunological Reviews·S Bartl
May 13, 1999·Immunological Reviews·L Abi RachedP Pontarotti
May 13, 1999·Immunological Reviews·M F FlajnikM Nonaka
May 13, 1999·Immunological Reviews·J KaufmanJ Salomonsen
Dec 26, 2002·Annual Review of Immunology·Attila KumánovicsKirsten Fischer Lindahl
Jun 28, 2007·BMC Evolutionary Biology·Jane D Funkhouser, Nathan N Aronson
Jul 16, 2009·BMC Genomics·Hannah V SiddleKatherine Belov
Jan 28, 2014·Developmental and Comparative Immunology·Shicui Zhang, Pengfei Cui
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y OhtaM F Flajnik
Dec 1, 2006·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Dimitar B IlievFrederick W Goetz
Jun 18, 2004·Immunological Reviews·Masaru Nonaka, Fumiko Yoshizaki
Mar 3, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jacques Robert, Yuko Ohta
Feb 22, 2012·Genesis : the Journal of Genetics and Development·Anita Abu-DayaLyle B Zimmerman
Aug 12, 2000·Fish & Shellfish Immunology·M Nonaka, S L Smith
Oct 2, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Xiaoyun YuBaojuan Dong
Jan 25, 2019·Immunogenetics·Masanori Kasahara, Martin F Flajnik
Jan 15, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tereza AlmeidaAna Veríssimo
Sep 16, 2005·Molecular Biology and Evolution·David H Bos, Bruce Waldman

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