PMID: 6982306Nov 1, 1982Paper

Major histocompatibility complex-restricted self-recognition in responses to trinitrophenyl-ficoll. Adaptive differentiation and self-recognition by B cells

The Journal of Experimental Medicine
A Singer, R J Hodes

Abstract

The present study has examined the possibility of TNP-Ficoll-responsive B cells recognize the MHC determinants expressed by the accessory cells with which they interact for the generation of T cell-independent responses to "high" concentrations (10(-2) micrograms/ml) of TNP-Ficoll. In experiments with B cells from normal mice, it was found that MHC homology between the TNP-Ficoll-responsive B cells and accessory cells was not required. Nevertheless, TNP-Ficoll-responsive B cells from both fully allogeneic (A leads to B) and F1 leads to parent radiation bone marrow chimeras were triggered by accessory cells expressing host-type, but not uniquely donor-type, MHC determinants. The MHC gene products responsible for this apparent B cell-accessory restriction were encoded in the left side, i.e., the K and/or I-A region, of H-2. Such genetic restrictions were shown not to be imposed by the residual T cells contaminating the chimeric B cell populations because T cell reconstitution experiments using "unrestricted" F1 T cells from normal mice did not fully overcome the marked preference of the chimeric B cells for accessory cells expressing appropriate (host-type) MHC determinants. To directly determine whether TNP-Ficoll-responsive B c...Continue Reading

References

Mar 1, 1978·The Journal of Experimental Medicine·R M ZinkernagelJ Klein
Jan 1, 1977·Immunological Reviews·D E MosierW E Paul
Aug 1, 1974·Journal of Immunological Methods·I A Ly, R I Mishell
Nov 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·M B Rittenberg, K L Pratt
Jan 1, 1980·Scandinavian Journal of Immunology·P C Doherty, J R Bennink
Apr 26, 1963·Science·N K Jerne, A A Nordin

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Citations

Nov 1, 1985·The Journal of Experimental Medicine·L H ShapiroJ E Neiderhuber
Jul 1, 1986·The Journal of Experimental Medicine·B G Froscher, N R Klinman
Oct 1, 1993·Immunological Reviews·P Matzinger
May 1, 1986·Annales De L'Institut Pasteur. Immunology·M A Le MoalP Truffa-Bachi
Feb 1, 1984·Immunology Today·R J Hodes, A Singer

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