Major late toxicities after conformal radiotherapy for nasopharyngeal carcinoma-patient- and treatment-related risk factors

International Journal of Radiation Oncology, Biology, Physics
Anne W M LeeSoren M Bentzen

Abstract

To retrospectively analyze the factors affecting late toxicity for nasopharyngeal carcinoma. Between 1998 and 2003, 422 patients were treated with a conformal technique with 2-Gy daily fractions to a total dose of 70 Gy. Conventional fractionation (5 fractions weekly) was used in 232 patients and accelerated fractionation (6 fractions weekly) in 190 patients. One hundred seventy-one patients were treated with the basic radiotherapy course alone (Group 1), 55 patients had an additional boost of 5 Gy in 2 fractions (Group 2), and 196 patients underwent concurrent cisplatin-based chemotherapy (Group 3). The 5-year overall toxicity rate was significantly greater in Group 3 than in Group 1 (37% vs. 27%, p = 0.009). Although the overall rate in Group 2 was not elevated (28% vs. 27%, p = 0.697), a significant increase in temporal lobe necrosis was observed (4.8% vs. 0%, p = 0.015). Multivariate analyses showed that age and concurrent chemotherapy were significant factors. The hazard ratio of overall toxicity attributed to chemotherapy was 1.99 (95% confidence interval, 1.32-2.99, p = 0.001). The mean radiation dose to the cochlea was another significant factor affecting deafness, with a hazard ratio of 1.03 (95% confidence interval, 1...Continue Reading

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Citations

Sep 17, 2013·World Journal of Surgical Oncology·Ke SaiZhong-ping Chen
Feb 14, 2013·Drug Design, Development and Therapy·Lu ZhangHai-Qiang Mai
Dec 3, 2010·Surgical Neurology International·Lola B ChamblessKyle D Weaver
Oct 16, 2013·Oral Oncology·Michael K M KamAnne W M Lee
Jun 13, 2012·Seminars in Radiation Oncology·Anne W M LeeWai T Ng
Jan 28, 2012·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jeffrey Kit Loong TuanJoseph Tien Seng Wee
Aug 24, 2010·Annales d'endocrinologie·W SialaJ Daoud
Jul 8, 2010·International Journal of Radiation Oncology, Biology, Physics·Siu Hong ChanAnne W M Lee
Jul 8, 2010·International Journal of Radiation Oncology, Biology, Physics·Richard L BakstSuzanne L Wolden
May 11, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Albiruni R A RazakKelvin Chan
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Jun 26, 2020·International Journal of Particle Therapy·Sarin KitpanitNancy Y Lee

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