Major orthopaedic surgeries for haemophilia with inhibitors using rFVIIa

Haemophilia : the Official Journal of the World Federation of Hemophilia
H TakedaniM Kajiwara

Abstract

Between 2000 and 2008, 11 major orthopaedic surgeries for 7 congenital haemophilia patients with inhibitors were performed by the first author as the primary doctor using recombinant activated factor VII (rFVIIa). Orthopaedic surgical treatments were performed for six surgeries for four high-responder haemophilia A patients, three surgeries for two high-responder haemophilia B patients and two surgeries for one low-responder haemophilia B patient. This low-responder patient is allergic to factor IX products, so he usually uses rFVIIa as a haemostatic agent. All of the surgeries were major, such as joint arthroplasty, arthroscopic synovectomy, and a combination of both, and excellent surgical results were achieved. Seven cases were controlled by bolus infusion of rFVIIa, and the other four cases were controlled by combined bolus and continuous infusion of rFVIIa. An anti-fibrolytic agent was used for all cases. There were no thrombogenic adverse effects, only two bleeding episodes. As for haemostatic control, nine surgeries were excellent, one was good and one was fair. This report is the largest clinical report on major orthopaedic surgeries at a single institute. We have concluded that the combination of bolus and continuous i...Continue Reading

References

Apr 24, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·J I LorenzoJ A Aznar
Nov 25, 2000·Seminars in Thrombosis and Hemostasis·S Schulman, UNKNOWN rFVIIa-CI Group
Nov 2, 2002·Haemophilia : the Official Journal of the World Federation of Hemophilia·R PerezR Sosa
Sep 27, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·E C Rodriguez-MerchanH Caviglia
Jan 31, 2004·Haemophilia : the Official Journal of the World Federation of Hemophilia·G TagarielloP G Davoli
May 11, 2006·Haemophilia : the Official Journal of the World Federation of Hemophilia·L P SolimenoE Santagostino
Sep 21, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·M MorfiniJ Tusell
Sep 21, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·E C Rodriguez-MerchanF Hernández-Navarro
Dec 18, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·A ObergfellP Mathew
Jul 17, 2008·Seminars in Hematology·Victor Jiménez-YusteFernando Hernandez-Navarro
Aug 30, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·J M TeitelN Zourikian
May 13, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·P SalajU Hedner

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Citations

Feb 8, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·L A ValentinoB Goldstein
Nov 20, 2012·British Journal of Haematology·Peter W CollinsUNKNOWN UK Haemophilia Centre Doctors
Aug 15, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·K ShimadaK Yamasaki
Aug 29, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·R Kulkarni
Jun 12, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·J HiroseT Koibuchi
Dec 2, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·A BoadasA Ruiz-Sáez
Dec 16, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·A Shapiro, D L Cooper
Dec 19, 2014·Haemophilia : the Official Journal of the World Federation of Hemophilia·H TakedaniN Ishiguro
Oct 1, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Christian CarulliMassimo Innocenti
Dec 7, 2018·Haemophilia : the Official Journal of the World Federation of Hemophilia·Gurhan ErturanNicholas J Goddard

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