Major review: Molecular genetics of primary open-angle glaucoma

Experimental Eye Research
Yutao Liu, R Rand Allingham

Abstract

Glaucoma is a leading cause of irreversible blindness worldwide. Primary open-angle glaucoma (POAG), the most common type, is a complex inherited disorder that is characterized by progressive retinal ganglion cell death, optic nerve head excavation, and visual field loss. The discovery of a large, and growing, number of genetic and chromosomal loci has been shown to contribute to POAG risk, which carry implications for disease pathogenesis. Differential gene expression analyses in glaucoma-affected tissues as well as animal models of POAG are enhancing our mechanistic understanding in this common, blinding disorder. In this review we summarize recent developments in POAG genetics and molecular genetics research.

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Citations

Jan 31, 2018·Eye·Anthony P Khawaja, Ananth C Viswanathan
Sep 7, 2018·Journal of Glaucoma·Reza AlizadehJoseph Caprioli
Mar 19, 2019·Current Opinion in Ophthalmology·Sayoko E MoroiJulia E Richards
Jan 7, 2019·The British Journal of Ophthalmology·Lei LeiChun Zhang
May 12, 2020·Investigative Ophthalmology & Visual Science·Hannah YoungbloodYutao Liu
Sep 13, 2019·Expert Opinion on Therapeutic Patents·Silvia Bua, Claudiu T Supuran
Aug 25, 2020·Translational Vision Science & Technology·Jingwen CaiYutao Liu
Mar 23, 2019·Investigative Ophthalmology & Visual Science·Min ChenKaijun Wang
Mar 11, 2020·Disease Models & Mechanisms·Cassandre Labelle-DumaisK Saidas Nair
Jun 29, 2018·Frontiers in Immunology·Ghanshyam Swarup, Zuberwasim Sayyad
May 31, 2018·Molecular Medicine Reports·Hong-Wei WangFeng Gao
Jun 18, 2020·International Journal of Molecular Sciences·Wioletta Rozpędek-KamińskaIreneusz Majsterek
Apr 24, 2018·Frontiers in Cell and Developmental Biology·Howard R Petty
Dec 9, 2020·Ophthalmic Genetics·Marcelo Luís OcchiuttoVital Paulino Costa
Dec 18, 2020·JAMA Ophthalmology·Xikun HanStuart MacGregor
Dec 11, 2019·Journal of Glaucoma·Ernst B van der MerweDavid Meyer
Feb 20, 2021·Investigative Ophthalmology & Visual Science·Brian S ColeJoan M O'Brien
Mar 9, 2021·The Journal of Physical Chemistry. B·Yuan GaoAnant K Paravastu
Mar 7, 2021·International Journal of Molecular Sciences·Saray TabakElie Beit-Yannai
Mar 17, 2021·Investigative Ophthalmology & Visual Science·Jessica M SkeieMark A Greiner
May 29, 2021·PloS One·Wouter H G HubensTheo G M F Gorgels

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