Making a Notch in the lymphocyte kit

European Journal of Immunology
H R Rodewald

Abstract

The receptor tyrosine kinase c-Kit plays crucial roles in lymphocyte development but there is little information on the molecular circuitry enforcing c-Kit expression. In addition to growth factors, Notch signaling is essential for T cell development. In this issue of the European Journal of Immunology, evidence is provided for an interesting link between c-Kit and Notch. The primary 'test subjects' were a Pax5-deficient 'pro-B cell' line, blocked in its B cell potential, and its non-mutated counterpart, a bone marrow-derived early progenitor with lymphoid and myeloid potential (EPLM). Similar to common lymphoid progenitors, EPLM have a 'B cell-biased' potential, yet show multipotency under appropriate conditions. Following Notch signaling, c-Kit expression was very rapidly upregulated and the development into T cells was found to be c-Kit-dependent. In the absence of Notch signals, c-Kit expression remained low. Development into non-T cell fates (NK or myeloid) was found to be c-Kit-independent. It remains to be determined whether c-Kit is a 'direct' target of the Notch signal transduction pathway; however, these findings, together with those of others, strongly suggest that Notch can contribute to the proper cytokine receptor...Continue Reading

References

May 29, 1998·Current Opinion in Immunology·J P Di Santo, H R Rodewald
Mar 14, 2000·Current Opinion in Immunology·M BusslingerA G Rolink
May 15, 2002·Immunology Letters·Antonius G RolinkFritz Melchers
Dec 14, 2002·Immunity·Thomas M Schmitt, Juan Carlos Zúñiga-Pflücker
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Avinash BhandoolaBenjamin Schwarz
Mar 17, 2004·Current Opinion in Immunology·Freddy RadtkeH Robson MacDonald
Mar 17, 2004·The Journal of Experimental Medicine·Valter AgostiPeter Besmer
Jun 5, 2004·Blood·Claudia WaskowHans-Reimer Rodewald
Aug 10, 2004·Nature Immunology·Benjamin A Schwarz, Avinash Bhandoola
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sonja HöflingerMeinrad Busslinger
Jun 23, 2005·European Journal of Immunology·Gina BalciunaiteAntonius G Rolink
Jun 23, 2005·European Journal of Immunology·Juan Carlos Zúñiga-Pflücker, Thomas M Schmitt
Jun 29, 2005·The Journal of Experimental Medicine·Claudia Benz, Conrad C Bleul
Feb 17, 2006·European Journal of Immunology·Steffen MassaAntonius G Rolink

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Citations

Jul 11, 2009·International Journal of Colorectal Disease·Christian KlinkVolker Schumpelick
Jul 19, 2006·The Journal of Experimental Medicine·Andreas KruegerHarald von Boehmer
Feb 12, 2010·Annals of the New York Academy of Sciences·Prabir RayAnuradha Ray
Mar 1, 2007·Blood·Claudia WaskowHans-Reimer Rodewald

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