Making ends meet in genetic analysis using padlock probes

Human Mutation
Mats NilssonU Landegren

Abstract

Padlock probes are molecular tools that combine highly specific target sequence recognition with the potential for multiplexed analysis of large sets of target DNA or RNA sequences. In this brief review, we exemplify the ability of these probes to distinguish single-nucleotide target sequence variants. We further discuss means to detect the location of target sequences in situ, and to amplify reacted padlock probes via rolling-circle replication, as well as to sort reaction products on tag-arrays. We argue that the probes have the potential to render high-throughput genetic analyses precise and affordable.

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Citations

Apr 8, 2003·Trends in Biotechnology·Vadim V Demidov
Apr 4, 2006·Nucleic Acids Research·Erik PetterssonAfshin Ahmadian
Aug 22, 2003·Nucleic Acids Research·Johan BanérMats Nilsson
Mar 9, 2004·Nucleic Acids Research·Michiel J T van EijkPieter Vos
Jul 20, 2010·Annual Review of Analytical Chemistry·Tim ConzeUlf Landegren
Jun 16, 2007·BMC Bioinformatics·Jason D Gans, Murray Wolinsky
Dec 28, 2005·Trends in Biotechnology·Mats NilssonJohan Stenberg
Jan 1, 2011·Cancers·Silvia CatuognoVittorio De Franciscis
May 8, 2003·European Journal of Human Genetics : EJHG·Dan-Oscar AntsonMats Nilsson
May 6, 2003·Nature Biotechnology·Paul HardenbolRonald W Davis
Feb 27, 2003·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Xiang Qian, Ricardo V Lloyd
Oct 9, 2004·BioTechniques·Rowena F SternCaroline Mackie Ogilvie
Nov 30, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Peter J Oefner

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