Making ends meet: repairing breaks in bacterial DNA by non-homologous end-joining

PLoS Genetics
Richard P Bowater, Aidan J Doherty

Abstract

DNA double-strand breaks (DSBs) are one of the most dangerous forms of DNA lesion that can result in genomic instability and cell death. Therefore cells have developed elaborate DSB-repair pathways to maintain the integrity of genomic DNA. There are two major pathways for the repair of DSBs in eukaryotes: homologous recombination and non-homologous end-joining (NHEJ). Until very recently, the NHEJ pathway had been thought to be restricted to the eukarya. However, an evolutionarily related NHEJ apparatus has now been identified and characterized in the prokarya. Here we review the recent discoveries concerning bacterial NHEJ and discuss the possible origins of this repair system. We also examine the insights gained from the recent cellular and biochemical studies of this DSB-repair process and discuss the possible cellular roles of an NHEJ pathway in the life-cycle of prokaryotes and phages.

References

Mar 23, 1990·Cell·S ThodeW Vielmetter
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D B Roth, J H Wilson
Oct 1, 1985·Molecular and Cellular Biology·D B RothJ H Wilson
Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E Winocour, I Keshet
Oct 1, 1982·Molecular and Cellular Biology·J H WilsonJ M Pipas
Feb 1, 1994·Molecular and Cellular Biology·P PfeifferW Vielmetter
Jul 31, 1997·Nature·T E WilsonM R Lieber
Jul 25, 1998·Advances in Genetics·P A Jeggo
Jul 25, 1998·Mutation Research·B A Bridges
Nov 12, 1998·Trends in Biochemical Sciences·S E Critchlow, S P Jackson
Apr 11, 2000·Molecular and Cellular Biology·S A Nick McElhinnyD A Ramsden
Jun 16, 2000·The Journal of Biological Chemistry·L ChenA E Tomkinson
Mar 10, 2001·Nature·S T ColeB G Barrell
Jul 4, 2001·Nature Reviews. Genetics·S M Rosenberg
Jul 10, 2001·Molecular Microbiology·A WilkinsonR Bowater
Jul 11, 2001·FEBS Letters·A J DohertyG R Weller
Sep 22, 2001·FEBS Letters·G R Weller, A J Doherty
Oct 10, 2001·Structure·J M JonesW Yang
Nov 24, 2001·Current Biology : CB·A J Doherty, S P Jackson
Sep 7, 2002·Science·Geoffrey R WellerAidan J Doherty
Jan 10, 2003·Nucleic Acids Research·Ikuo Uchiyama
Jan 11, 2003·Science·Smadar Levin-ZaidmanAbraham Minsky
Jan 14, 2003·EMBO Reports·Fabrizio d'Adda di FagagnaStephen P Jackson
Feb 11, 2003·Trends in Biochemical Sciences·Thomas E WilsonPhillip L Palmbos
May 3, 2003·The EMBO Journal·Erich HeidenreichUlrike Wintersberger
May 31, 2003·Science·Ivana BjedovIvan Matic
Feb 27, 2004·The Journal of Biological Chemistry·Chunling GongStewart Shuman
Mar 9, 2004·Current Opinion in Plant Biology·Alfred PühlerFergal O'Gara
Mar 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Anthony G TsolakiPeter M Small
May 4, 2004·Nature Reviews. Molecular Cell Biology·Jessica A Downs, Stephen P Jackson
May 14, 2004·Annual Review of Biophysics and Biomolecular Structure·Abraham Minsky
May 20, 2004·Journal of Bacteriology·Daphna Frenkiel-KrispinSharon Grayer Wolf
Jun 23, 2004·Research in Microbiology·Ivan MaticMiroslav Radman
Jun 23, 2004·Research in Microbiology·Megan N HershSusan M Rosenberg

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Citations

May 29, 2007·Nature Genetics·Jeanine M Pennington, Susan M Rosenberg
Jun 6, 2007·Antimicrobial Agents and Chemotherapy·Malgorzata Korycka-MachalaJarosław Dziadek
Nov 15, 2007·Nucleic Acids Research·Humberto SanchezJuan C Alonso
Oct 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Fanglei ZhuangAlan M Lambowitz
Mar 4, 2010·Microbiology and Molecular Biology Reviews : MMBR·Gerda HorneckRocco L Mancinelli
May 14, 2010·Cold Spring Harbor Perspectives in Biology·Alan M Lambowitz, Steven Zimmerly
Jul 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Taegun KwonDavid L Herrin
Jun 4, 2011·PloS One·Zhongdao LiXian-En Zhang
Sep 21, 2010·Cellular and Molecular Life Sciences : CMLS·Hermann Ragg
May 18, 2007·Annual Review of Microbiology·Robert S PitcherAidan J Doherty
Feb 14, 2016·Current Opinion in Biotechnology·Raissa Estrela, Jamie Harrison Doudna Cate
Jun 7, 2011·FEBS Letters·Lisa Postow
Aug 10, 2007·Critical Reviews in Biochemistry and Molecular Biology·P J Hastings
Aug 10, 2007·Critical Reviews in Biochemistry and Molecular Biology·Erich Heidenreich
Oct 6, 2007·Critical Reviews in Biochemistry and Molecular Biology·Rodrigo S GalhardoSusan M Rosenberg
Jun 24, 2008·Critical Reviews in Biochemistry and Molecular Biology·Melanie BlasiusUlrich Hübscher
Jun 3, 2014·The Journal of Physiology·James A Shapiro
Oct 27, 2011·Seminars in Cell & Developmental Biology·Torben R Kasparek, Timothy C Humphrey
Dec 1, 2010·DNA Repair·Kevin Hiom
Mar 6, 2016·Trends in Biotechnology·Ioannis MougiakosJohn van der Oost
Dec 19, 2006·Journal of Molecular Biology·Robert S PitcherAidan J Doherty
Oct 16, 2015·Biotechnology and Bioengineering·Michelle L LuoChase L Beisel
Nov 27, 2007·The Plant Journal : for Cell and Molecular Biology·Obed W OdomDavid L Herrin
Oct 16, 2015·Scientific Reports·Chris R Reisch, Kristala L J Prather
Mar 26, 2015·ACS Synthetic Biology·Yaojun TongSang Yup Lee
Nov 4, 2015·Molecular Genetics and Genomics : MGG·Marinalva Martins-PinheiroRenata M A da Costa
Apr 10, 2016·Nucleic Acids Research·Lun Cui, David Bikard
Apr 27, 2011·FEMS Microbiology Reviews·Silvia AyoraJuan C Alonso
Jan 25, 2011·Molecular Cell·Nigel C BrissettAidan J Doherty
Sep 5, 2006·Molecular Cell·Robert S PitcherAidan J Doherty
Mar 22, 2015·Mutation Research. Reviews in Mutation Research·Victoria L Fell, Caroline Schild-Poulter
Oct 31, 2014·Nucleic Acids Research·Ana de OryMiguel de Vega

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