Making genomics functional: deciphering the genetics of acute lung injury.

Proceedings of the American Thoracic Society
Ryan KampJoe G N Garcia

Abstract

Acute lung injury (ALI) is a common and frequently devastating illness characterized by acute hypoxemic respiratory failure, profound inflammation, and flooding of the alveoli. Despite recent advances in ALI care, the morbidity and mortality of ALI continues to be unacceptably high. ALI-inciting events (e.g., sepsis, trauma, aspiration, pneumonia) are quite common, yet only a fraction of patients develop the syndrome. This heterogeneity of patients presenting with ALI has sparked interest in identifying the role of genetic factors that contribute to ALI susceptibility and prognosis. Recent advances in high-throughput sequencing and expression technologies now provide the tools to perform large-scale genomic analyses in complex disorders such as ALI; gene expression profiling and pathway analysis provide further insight into previously described molecular pathways involved in the syndrome. In this article, we describe the use of genomewide association studies, ortholog in silico techniques, utility of consomic rat methods, and candidate gene approaches using expression profiling and pathway analyses. These methods have confirmed suspected ALI candidate genes (e.g., IL-6 and MIF), but more impressively have identified novel genes...Continue Reading

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Citations

Oct 5, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kathleen A StringerTheodore J Standiford
Mar 13, 2010·American Journal of Respiratory and Critical Care Medicine·Roger G SpraggAndrea L Harabin
Jun 29, 2010·American Journal of Respiratory and Critical Care Medicine·Douglas ArenbergAlisa E Koch
Jul 10, 2012·American Journal of Respiratory Cell and Molecular Biology·Xiaoguang SunJoe G N Garcia
Aug 21, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Keely L SzilágyiJoe G N Garcia
Feb 10, 2018·American Journal of Respiratory and Critical Care Medicine·Christian BimeJoe G N Garcia
Feb 6, 2017·Cellular and Molecular Life Sciences : CMLS·Michael SchnoorAlexander Zarbock
Mar 29, 2011·Critical Care Clinics·L J Mark Cross, Michael A Matthay

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