Making Mice Mighty: recent advances in translational models of load-induced muscle hypertrophy.

Journal of Applied Physiology
Kevin A MurachCory M Dungan

Abstract

The ability to genetically manipulate mice allows for gain- and loss-of-function in vivo, making them an ideal model for elucidating mechanisms of skeletal muscle mass regulation. Combining genetic models with mechanical muscle loading enables identification of specific factors involved in the hypertrophic response as well as the ability to test the requirement of those factors for adaptation, thereby informing performance and therapeutic interventions. Until recently, approaches for inducing mechanically mediated muscle hypertrophy (i.e., resistance-training analogs) have been limited and considered "nontranslatable" to humans. This mini-review outlines recent translational advances in loading-mediated strategies for inducing muscle hypertrophy in mice, and highlights the advantages and disadvantages of each method. The skeletal muscle field is poised for new breakthroughs in understanding mechanisms regulating load-induced muscle growth given the numerous murine tools that have very recently been described.

References

Dec 1, 1990·Journal of Applied Physiology·B F Timson
Aug 1, 1988·Journal of Applied Physiology·T S Wong, F W Booth
Apr 1, 1988·Journal of Applied Physiology·H Klitgaard
Nov 1, 1967·The American Journal of Physiology·A L Goldberg
Aug 1, 1995·Comparative Biochemistry and Physiology. Part A, Physiology·R R Roy, V R Edgerton
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·A C McPherron, S J Lee
Jun 11, 1998·Journal of Applied Physiology·A IshiharaV R Edgerton
Apr 12, 2001·Journal of Applied Physiology·D L AllenL A Leinwand
Feb 13, 2002·The Journal of Orthopaedic and Sports Physical Therapy·Dawn A Lowe, Stephen E Alway
Feb 22, 2002·Experimental Physiology·Akihiko IshiharaShigeru Katsuta
May 30, 2003·Experimental Biology and Medicine·Stephen M RothMarc A Rogers
Mar 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·John P KonhilasLeslie A Leinwand
Sep 30, 2006·Journal of Applied Physiology·John J McCarthy, Karyn A Esser
Nov 26, 2010·Muscle & Nerve·Jarrod A CallDawn A Lowe
Aug 11, 2011·Development·John J McCarthyCharlotte A Peterson
Oct 22, 2011·Exercise and Sport Sciences Reviews·Kieran F Reid, Roger A Fielding
May 9, 2012·Skeletal Muscle·John J McCarthyKaryn A Esser
May 31, 2013·Comprehensive Physiology·Gregory R Adams, Marcas M Bamman
Jul 23, 2013·Journal of Applied Physiology·Thomas ChaillouJohn J McCarthy
Apr 2, 2014·The Journal of Physiology·Christopher S FryCharlotte A Peterson
Feb 6, 2015·Scandinavian Journal of Medicine & Science in Sports·Z SoffeT Shavlakadze
Oct 24, 2015·Journal of Applied Physiology·Justin P HardeeJames A Carson
Apr 18, 2016·Metabolism: Clinical and Experimental·Andy V KhamouiJeong-Su Kim
Aug 7, 2016·Methods in Molecular Biology·Tyler J KirbyChristopher S Fry
Sep 22, 2016·Physiological Reports·Kevin A MurachCharlotte A Peterson
Jun 22, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kenneth Ladd SeldeenBruce Robert Troen
Dec 8, 2017·Journal of Cachexia, Sarcopenia and Muscle·Justin P HardeeJames A Carson
May 17, 2018·Science Signaling·Jae-Sung YouTroy A Hornberger
Jun 19, 2018·Frontiers in Physiology·Sander A J VerbruggeHenning Wackerhage
Dec 5, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jae-Sung YouTroy A Hornberger
Jan 15, 2019·Exercise and Sport Sciences Reviews·Kevin A MurachJohn J McCarthy
Mar 7, 2019·American Journal of Physiology. Cell Physiology·Cory M DunganCharlotte A Peterson

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Citations

Sep 4, 2020·Journal of Cachexia, Sarcopenia and Muscle·Kevin A MurachCory M Dungan
May 12, 2021·Seminars in Cell & Developmental Biology·Vikram Prasad, Douglas P Millay
Jul 25, 2021·Cancers·Dean G CampeljEmma Rybalka
Aug 10, 2021·Frontiers in Cell and Developmental Biology·Maria J A van Ingen, Tyler J Kirby
Sep 5, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kevin A MurachCharlotte A Peterson
Sep 28, 2021·The Journal of Physiology·Taylor R ValentinoJohn J McCarthy

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