Making myc

Current Topics in Microbiology and Immunology
J Liu, D Levens

Abstract

Myc regulates to some degree every major process in the cell. Proliferation, growth, differentiation, apoptosis, and metabolism are all under myc control. In turn, these processes feed back to adjust the level of c-myc expression. Although Myc is regulated at every level from RNA synthesis to protein degradation, c-myc transcription is particularly responsive to multiple diverse physiological and pathological signals. These signals are delivered to the c-myc promoter by a wide variety of transcription factors and chromatin remodeling complexes. How these diverse and sometimes disparate signals are processed to manage the output of the c-myc promoter involves chromatin, recruitment of the transcription machinery, post-initiation transcriptional regulation, and mechanisms to provide dynamic feedback. Understanding these mechanisms promises to add new dimensions to models of transcriptional control and to reveal new strategies to manipulate Myc levels.

Citations

Nov 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Lawrence R BenjaminDavid Levens
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jose SoteloXiaolin Wu
Sep 13, 2006·The FEBS Journal·Inken Wierstra, Jürgen Alves
Jul 9, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elena HartmannElías Campo
Nov 20, 2009·Annual Review of Pharmacology and Toxicology·Verónica González, Laurence H Hurley
Jul 26, 2008·Journal of Virology·Haggit Ben-IsraelTamar Kleinberger
May 1, 2021·Antioxidants·Saniya ArfinDhruv Kumar
Jan 10, 2012·Gene·Bernhard Lüscher, Jörg Vervoorts
May 9, 2012·Seminars in Cancer Biology·Joana Alves Vidigal, Andrea Ventura

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