Making preventive medicine more personalized: implications for exercise-related research.

Preventive Medicine
Thomas W Buford, Marco Pahor

Abstract

This commentary offers a discussion of the need to consider behavioral interventions such as physical exercise as integral components of personalized medicine. We discuss the concept of personalized medicine and review existing evidence of variability in response to exercise training. We argue that increased understanding is needed regarding sources of variability in exercise responsiveness, and that such understanding should lead to more tailored, often multimodal interventions. Studies of personalized medicine to date have primarily investigated heterogeneity in drug responsiveness; we believe it is time to begin considering preventive strategies such as exercise within a broader scope of personalized care.

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Citations

Dec 24, 2013·PM & R : the Journal of Injury, Function, and Rehabilitation·Thomas W BufordMatthew B Cooke
Feb 6, 2013·Sports Medicine·Thomas W BufordTimothy S Church
Aug 29, 2016·Archives of Physical Medicine and Rehabilitation·Andrew S LayneUNKNOWN LIFE Study Investigators
May 12, 2017·Journal of Human Genetics·Sho NakamuraTakamasa Kayama
Sep 14, 2019·Journal of Neurologic Physical Therapy : JNPT·Sarah KlamrothSimon Steib
Jul 25, 2019·European Review of Aging and Physical Activity : Official Journal of the European Group for Research Into Elderly and Physical Activity·Fabian HeroldNotger G Müller
Sep 14, 2017·Journal of Neuroengineering and Rehabilitation·Dylan KobsarReed Ferber
Jun 30, 2019·Sports Medicine·Scott J Dankel, Jeremy P Loenneke
Nov 19, 2019·Frontiers in Psychology·Fabian HeroldNotger G Müller
May 1, 2021·Journal of Clinical Medicine·Fernando Estévez-LópezMaría J Álvarez-Cubero

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