Making the invisible enemy visible.

BioRxiv : the Preprint Server for Biology
Tristan CrollAndrea Thorn

Abstract

During the COVID-19 pandemic, structural biologists have rushed to solve the structures of the 28 proteins encoded by the SARS-CoV-2 genome in order to understand the viral life cycle and enable structure-based drug design. In addition to the 200 structures from SARS-CoV previously solved, 367 structures covering 16 of the viral proteins have been released in the span of only 6 months. These structural models serve as basis for research worldwide to understand how the virus hijacks human cells, for structure-based drug design and to aid in the development of vaccines. However, errors often occur in even the most careful structure determination - and are even more common among these structures, which were solved under immense pressure. From the beginning of the pandemic, the Coronavirus Structural Taskforce has categorized, evaluated and reviewed all of these experimental protein structures in order to help downstream users and original authors. Our website also offers improved models for many key structures, which have been used by Folding@Home, OpenPandemics, the EU JEDI COVID-19 challenge, and others. Here, we describe our work for the first time, give an overview of common problems, and describe a few of these structures tha...Continue Reading

Citations

Jan 14, 2021·Nature Structural & Molecular Biology·Montserrat BárcenaQiang Zhou
Apr 14, 2021·Expert Review of Molecular Diagnostics·Davide ZellaMassimo Ciccozzi

Methods Mentioned

BETA
ice crystal diffraction
X-ray

Related Concepts

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