Making Time: Conservation of Biological Clocks from Fungi to Animals

Microbiology Spectrum
J C Dunlap, Jennifer J Loros

Abstract

The capacity for biological timekeeping arose at least three times through evolution, in prokaryotic cyanobacteria, in cells that evolved into higher plants, and within the group of organisms that eventually became the fungi and the animals. Neurospora is a tractable model system for understanding the molecular bases of circadian rhythms in the last of these groups, and is perhaps the most intensively studied circadian cell type. Rhythmic processes described in fungi include growth rate, stress responses, developmental capacity, and sporulation, as well as much of metabolism; fungi use clocks to anticipate daily environmental changes. A negative feedback loop comprises the core of the circadian system in fungi and animals. In Neurospora, the best studied fungal model, it is driven by two transcription factors, WC-1 and WC-2, that form the White Collar Complex (WCC). WCC elicits expression of the frq gene. FRQ complexes with other proteins, physically interacts with the WCC, and reduces its activity; the kinetics of these processes is strongly influenced by progressive phosphorylation of FRQ. When FRQ becomes sufficiently phosphorylated that it loses the ability to influence WCC activity, the circadian cycle starts again. Enviro...Continue Reading

References

Sep 1, 1979·Journal of Bacteriology·D Mattern, S Brody
Apr 19, 1996·Science·G Tosini, M Menaker
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·D Bell-PedersenJ C Dunlap
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·M W MerrowJ C Dunlap
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y OuyangC H Johnson
Aug 7, 1998·Science·Y LiuJ C Dunlap
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·S SuganoE M Tobin
Feb 13, 1999·Cell·J C Dunlap
Jun 5, 1999·Microbiology and Molecular Biology Reviews : MMBR·B L Taylor, I B Zhulin
Sep 16, 1999·Cellular and Molecular Life Sciences : CMLS·Y LiuJ C Dunlap
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·P L Lakin-Thomas, S Brody
Apr 4, 2000·Current Opinion in Microbiology·H Iwasaki, J C Dunlap
Feb 22, 2001·Annual Review of Physiology·J J Loros, J C Dunlap
Apr 18, 2002·Genes & Development·Yuhong YangYi Liu
Apr 10, 2003·Eukaryotic Cell·Andrew V GreeneDeborah Bell-Pedersen
Jun 28, 2003·Journal of Biological Rhythms·Yi Liu
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Alejandro CorreaDeborah Bell-Pedersen
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mariko IzumoShin Yamazaki
Feb 12, 2004·Genes & Development·Yuhong YangYi Liu
Jul 13, 2004·Journal of Biological Rhythms·Melinda K ChristensenPeter Ruoff
Nov 10, 2004·Journal of Biological Rhythms·Jay C Dunlap, Jennifer J Loros
Dec 31, 2004·Genes & Development·Ping ChengYi Liu
Nov 30, 2005·Proceedings of the National Academy of Sciences of the United States of America·Peter RuoffJay C Dunlap
May 1, 1971·Plant Physiology·J A BourretB H Carpenter

❮ Previous
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Citations

May 16, 2018·Journal of Biological Rhythms·Gustavo B S RivasRafaela Vieira Bruno
Jan 30, 2018·Frontiers in Microbiology·Eva StapplerMonika Schmoll
Nov 1, 2018·Nature Reviews. Microbiology·Zhenzhong Yu, Reinhard Fischer
Jun 21, 2019·Journal of Biological Rhythms·Stuart Brody
Aug 28, 2019·Annual Review of Genetics·Luis M Corrochano
Dec 27, 2019·Journal of Biological Rhythms·Stuart Brody
Dec 28, 2019·Journal of Biological Rhythms·Bala S C KoritalaKwangwon Lee
Jun 7, 2019·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Carmen Ruger-Herreros, Luis M Corrochano
Jan 29, 2019·The European Journal of Neuroscience·Jennifer J Loros
Sep 12, 2018·Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life·Zewei LiJohn Tower
Jul 10, 2019·Annual Review of Microbiology·Yi Zhen Deng, Naweed I Naqvi
Dec 15, 2018·The European Journal of Neuroscience·Helen C Causton
Mar 19, 2019·The Plant Journal : for Cell and Molecular Biology·Eric PolinerEva M Farré
May 2, 2018·Fungal biology and biotechnology·Monika Schmoll
Jun 28, 2019·Frontiers in Endocrinology·Francisco Javier Sánchez-VázquezJesús M Míguez
Apr 3, 2020·International Journal of Molecular Sciences·Claus Behn, Nicole De Gregorio
Dec 22, 2020·Chronobiology International·Swetha Gopalakrishnan, Nisha N Kannan
Nov 13, 2020·Cell Communication and Signaling : CCS·Jacqueline F PelhamJennifer M Hurley
Apr 2, 2021·G3 : Genes - Genomes - Genetics·Felipe Muñoz-GuzmánLuis F Larrondo
Jul 1, 2021·The FEBS Journal·Anne PelikanBharath Ananthasubramaniam
Oct 1, 2021·Nature·Matt UlgheraitMimi Shirasu-Hiza
Nov 4, 2021·Chronobiology International·Hans G RichterCarlos Spichiger
Oct 27, 2021·The FEBS Journal·Yao D Cai, Joanna C Chiu
Dec 28, 2021·Archives of Microbiology·Luciana P DiasDrauzio E N Rangel

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