Making useful gadgets with miniaturized G proteins.

The Journal of Biological Chemistry
Kirill A Martemyanov, Mikel Garcia-Marcos

Abstract

G protein-coupled receptors (GPCRs) relay information from extracellular stimuli to intracellular responses in a wide range of physiological and pathological processes, but understanding their complex effects in live cells is a daunting task. In this issue of JBC, Wan et al repurpose "mini G proteins"-previously used as affinity tools for structural studies-to develop a suite of probes to visualize GPCR activation in live cells. The approach is expected to revolutionize our understanding of the spatiotemporal control and mechanisms of GPCR signaling.

References

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Mar 11, 2018·The Journal of Biological Chemistry·Qingwen WanNevin A Lambert

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