Making Waves: New Developments in Toxicology With the Zebrafish

Toxicological Sciences : an Official Journal of the Society of Toxicology
Katharine A Horzmann, Jennifer L Freeman

Abstract

The laboratory zebrafish (Danio rerio) is now an accepted model in toxicologic research. The zebrafish model fills a niche between in vitro models and mammalian biomedical models. The developmental characteristics of the small fish are strategically being used by scientists to study topics ranging from high-throughput toxicity screens to toxicity in multi- and transgenerational studies. High-throughput technology has increased the utility of zebrafish embryonic toxicity assays in screening of chemicals and drugs for toxicity or effect. Additionally, advances in behavioral characterization and experimental methodology allow for observation of recognizable phenotypic changes after xenobiotic exposure. Future directions in zebrafish research are predicted to take advantage of CRISPR-Cas9 genome editing methods in creating models of disease and interrogating mechanisms of action with fluorescent reporters or tagged proteins. Zebrafish can also model developmental origins of health and disease and multi- and transgenerational toxicity. The zebrafish has many advantages as a toxicologic model and new methodologies and areas of study continue to expand the usefulness and application of the zebrafish.

References

Jul 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C B KimmelT F Schilling
Mar 28, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M E HurttA Browning
Feb 11, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Adrian J HillRichard E Peterson
Oct 28, 2008·Neurotoxicology·R C MacPhailS Padilla
May 19, 2009·Reproductive Toxicology·Ingrid W T SelderslaghsHilda E Witters
Feb 19, 2010·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Kimberly C BrannenKaren A Augustine-Rauch
Aug 30, 2011·Neurotoxicology and Teratology·S PadillaR C MacPhail
Sep 21, 2011·Birth Defects Research. Part C, Embryo Today : Reviews·Nisha S SipesThomas B Knudsen
Oct 25, 2011·Annual Review of Pharmacology and Toxicology·Randall T Peterson, Calum A Macrae
Dec 21, 2011·Reproductive Toxicology·S PadillaD M Reif
Aug 14, 2012·Journal of Neuroscience Methods·Jeremy GreenAllan V Kalueff
Sep 8, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Thaddeus T SchugJerold J Heindel
Jan 31, 2013·Nature Biotechnology·Woong Y HwangJ Keith Joung
Mar 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David KokelRandall T Peterson
Mar 26, 2013·Current Medicinal Chemistry·Y GibertA C Ward
Apr 18, 2013·Zebrafish·Allan V KalueffUNKNOWN Zebrafish Neuroscience Research Consortium
May 11, 2013·Biochimica Et Biophysica Acta·Tomoyuki Sasaki, Shuji Kishi
Jun 1, 2013·Birth Defects Research. Part C, Embryo Today : Reviews·Jordan BaileyEdward D Levin
Jul 3, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tracie R BakerWarren Heideman
Jul 23, 2013·PloS One·Woong Y HwangJing-Ruey Joanna Yeh
Aug 7, 2013·Proceedings of the National Academy of Sciences of the United States of America·Li-En JaoWenbiao Chen
Oct 19, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lisa TruongRobert L Tanguay
Jan 29, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tracie R BakerWarren Heideman
Mar 25, 2014·Translational Research : the Journal of Laboratory and Clinical Medicine·Eric E Nilsson, Michael K Skinner
Jun 1, 2014·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Pål A OlsvikStåle Ellingsen
Jun 29, 2014·Disease Models & Mechanisms·Jennifer B Phillips, Monte Westerfield
Aug 12, 2014·Congenital Anomalies·Yuhei NishimuraToshio Tanaka
Nov 16, 2014·Methods in Enzymology·Andrew P W Gonzales, Jing-Ruey Joanna Yeh
Nov 21, 2014·Development·Uwe IrionChristiane Nüsslein-Volhard
Dec 3, 2014·Current Opinion in Chemical Biology·Andrew J Rennekamp, Randall T Peterson
Dec 5, 2014·Journal of Developmental Origins of Health and Disease·A C HaugenJ J Heindel
Mar 11, 2015·Developmental Cell·Julien AblainLeonard I Zon
Apr 14, 2015·Nature Methods·Arish N ShahCecilia B Moens
Aug 5, 2015·Endocrinology·Jerrold J HeindelMark Hanson
Sep 1, 2015·Gastroenterology·Wolfram Goessling, Kirsten C Sadler
Sep 12, 2015·Nature Reviews. Drug Discovery·Calum A MacRae, Randall T Peterson
Sep 16, 2015·Aquatic Toxicology·Allan V KalueffUNKNOWN International Zebrafish Neuroscience Research Consortium ZNRC
Dec 4, 2015·Methods : a Companion to Methods in Enzymology·Rock Pulak
Dec 8, 2015·Advances in Genetics·Gaurav K VarshneyShawn M Burgess

❮ Previous
Next ❯

Citations

Oct 16, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jui-Hua HsiehMamta Behl
Oct 16, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Alexandra UlinLarissa M Williams
Dec 7, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Celia QuevedoAinhoa Alzualde
Feb 26, 2020·Disease Models & Mechanisms·Mark E Hahn, Kirsten C Sadler
Feb 28, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Henry LujanChristie Sayes
Jan 9, 2019·Frontiers in Neuroscience·Marta d'Amora, Silvia Giordani
Nov 24, 2020·Environmental Science and Pollution Research International·Carla Eliana DavicoEvelise Maria Nazari
Nov 22, 2020·The Science of the Total Environment·Vítor Otacílio de AlmeidaIvo André Homrich Schneider
Jan 10, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yujin Lee, Jaewook Yang
Oct 30, 2020·Molecular & Cellular Proteomics : MCP·Niels M LeijtenSimone Lemeer
Feb 9, 2021·Frontiers in Cell and Developmental Biology·Laura E KuilMaria M Alves
Nov 5, 2020·Journal of Toxicology and Environmental Health. Part a·Ola WaselJennifer L Freeman
May 7, 2020·Toxicology Reports·Janiel K Ahkin Chin Tai, Jennifer L Freeman
Mar 9, 2021·Critical Reviews in Food Science and Nutrition·Georg SandnerJulian Weghuber
Feb 18, 2021·Molecular & Cellular Proteomics : MCP·Niels M LeijtenSimone Lemeer
Mar 3, 2021·Experimental & Molecular Medicine·Tae-Young ChoiCheol-Hee Kim
Jul 14, 2020·Current Opinion in Toxicology·Tamara TalPamela J Lein
May 19, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Anyi WuYuanxiang Jin
Jun 27, 2021·Fish Physiology and Biochemistry·Francisco Javier Toledo-SolísMiguel Angel Sáenz de Rodrigáñez
Jul 3, 2021·Pharmaceuticals·Hissa F Al-ThaniHuseyin C Yalcin
Aug 5, 2021·The Science of the Total Environment·Monica Torres-RuizAna Isabel Cañas Portilla
Jun 11, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sebastian HoffmannKatya Tsaioun
Oct 19, 2019·Chemical Research in Toxicology·Steven CassarLeonard I Zon
Jun 23, 2020·Chemical Research in Toxicology·Jinyoung Lee, Jennifer L Freeman

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR (general)

Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). CRISPR-Cas system enables the editing of genes to create or correct mutations. Discover the latest research on CRISPR here.

CRISPR Ribonucleases Deactivation

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on mechanisms that underlie deactivation of CRISPR ribonucleases. Here is the latest research.

Related Papers

Biomedit︠s︡inskai︠a︡ khimii︠a︡
N F BeliaevaA I Archakov
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme
H Takeda
Environmental Science and Pollution Research International
H Hollert, Steffen H Keiter
© 2022 Meta ULC. All rights reserved