Makorin rings the kisspeptin bell to signal pubertal initiation.

The Journal of Clinical Investigation
Ali Abbara, Waljit S Dhillo

Abstract

The signals maintaining quiescence of the reproductive endocrine axis during childhood before its reawakening at puberty had been enigmatic. Studies in patients with abnormal puberty have illuminated the identity of the signals; kisspeptin has emerged as a major stimulator of puberty, and makorin RING finger protein 3 (MKRN3) as an inhibitory signal that prevents premature initiation of puberty. In this issue of the JCI, Abreu et al. investigated the mechanism by which MKRN3 regulates pubertal onset. The authors found that a reduction in MKRN3 alleviated the constraint on kisspeptin-expressing neurons to allow pubertal initiation, a phenomenon observed across species, including nonhuman primates. Further, the ubiquitinase activity of MKRN3 required its RING finger domain, in order to repress the promoter activity of genes encoding kisspeptin and neurokinin B. These data advance our understanding of the regulation of kisspeptin-expressing neurons by MKRN3 to initiate puberty.

References

Aug 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Nicolas de RouxEdwin Milgrom
Oct 24, 2003·The New England Journal of Medicine·Stephanie B SeminaraWilliam H Colledge
Jul 5, 2005·Science
Feb 15, 2008·The New England Journal of Medicine·Milena Gurgel TelesAna Claudia Latronico
Nov 21, 2009·The Journal of Clinical Endocrinology and Metabolism·Kaspar SørensenAnders Juul
Mar 20, 2010·The Journal of Clinical Endocrinology and Metabolism·L G SilveiraA C Latronico
Jun 4, 2013·European Journal of Pediatrics·Josko MarkicVedrana Cikes Culic
Feb 20, 2015·The Journal of Clinical Endocrinology and Metabolism·Casper P HagenAnders Juul
Feb 8, 2016·The Lancet. Diabetes & Endocrinology·Ana Paula Abreu, Ursula B Kaiser
Mar 31, 2016·European Journal of Endocrinology·Tero VarimoTaneli Raivio
Apr 9, 2016·The Journal of Clinical Endocrinology and Metabolism·Alexander S BuschAnders Juul
May 21, 2016·Nature Reviews. Endocrinology·Allan E Herbison
May 27, 2016·Neuroendocrinology·Danielle S BessaAna Claudia Latronico
Jul 17, 2018·Endocrinology·Aleisha M MooreMichael N Lehman
Oct 1, 2018·Hormone Research in Pædiatrics·Anna GrandoneEmanuele Miraglia Del Giudice
Jan 31, 2019·Endocrine Reviews·Jacques YoungNelly Pitteloud
Feb 26, 2019·Frontiers in Endocrinology·Venkatram YellapragadaTaneli Raivio
Feb 27, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hwal Rim JeongIl Tae Hwang
May 2, 2019·Journal of the Endocrine Society·Luciana Pinto ValadaresAdriana Lofrano-Porto
Jun 27, 2020·Journal of the Endocrine Society·Stephanie A RobertsUrsula B Kaiser

❮ Previous
Next ❯

Methods Mentioned

BETA
ubiquitination

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Clinical Endocrinology and Metabolism
Alexander S BuschAnders Juul
Journal of Molecular Endocrinology
Ana Paula AbreuAna Claudia Latronico
Annals of Pediatric Endocrinology & Metabolism
Young-Lim Shin
Current Opinion in Endocrine and Metabolic Research
Luigi MaioneUrsula B Kaiser
© 2021 Meta ULC. All rights reserved