Maladaptive Behavior and Gastrointestinal Disorders in Children with Autism Spectrum Disorder

Pediatric Gastroenterology, Hepatology & Nutrition
Hardiono D PusponegoroYvan Vandenplas

Abstract

Various gastrointestinal factors may contribute to maladaptive behavior in children with autism spectrum disorders (ASD). To determine the association between maladaptive behavior in children with ASD and gastrointestinal symptoms such as severity, intestinal microbiota, inflammation, enterocyte damage, permeability and absorption of opioid peptides. This observational cross-sectional study compared children with ASD to healthy controls, aged 2-10 years. Maladaptive behavior was classified using the Approach Withdrawal Problems Composite subtest of the Pervasive Developmental Disorder Behavior Inventory. Dependent variables were gastrointestinal symptom severity index, fecal calprotectin, urinary D-lactate, urinary lactulose/mannitol excretion, urinary intestinal fatty acids binding protein (I-FABP) and urinary opioid peptide excretion. We did not find a significant difference between children with ASD with severe or mild maladaptive behavior and control subjects for gastrointestinal symptoms, fecal calprotectin, urinary D-lactate, and lactulose/mannitol ratio. Urinary opioid peptide excretion was absent in all children. Children with ASD with severe maladaptive behavior showed significantly higher urinary I-FABP levels compare...Continue Reading

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Citations

Dec 19, 2015·The World Allergy Organization Journal·Y Vandenplas
Apr 4, 2017·British Journal of Pharmacology·Lucie P PellissierJulie Le Merrer
Sep 11, 2018·Beneficial Microbes·S SalvatoreY Vandenplas
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Jun 7, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lola Rueda-RuzafaPablo Roman
Oct 28, 2021·Critical Reviews in Food Science and Nutrition·Katarzyna TarnowskaRenata Winkler

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