Malaria and immunity during pregnancy and postpartum: a tale of two species

Parasitology
A R D McLeanFreya J I Fowkes

Abstract

It is well established that pregnant women are at an increased risk of Plasmodium falciparum infection when compared to non-pregnant individuals and limited epidemiological data suggest Plasmodium vivax risk also increases with pregnancy. The risk of P. falciparum declines with successive pregnancies due to the acquisition of immunity to pregnancy-specific P. falciparum variants. However, despite similar declines in P. vivax risk with successive pregnancies, there is a paucity of evidence P. vivax-specific immunity. Cross-species immunity, as well as immunological and physiological changes that occur during pregnancy may influence the susceptibility to both P. vivax and P. falciparum. The period following delivery, the postpartum period, is relatively understudied and available epidemiological data suggests that it may also be a period of increased risk of infection to Plasmodium spp. Here we review the literature and directly compare and contrast the epidemiology, clinical pathogenesis and immunological features of P. vivax and P. falciparum in pregnancy, with a particular focus on studies performed in areas co-endemic for both species. Furthermore, we review the intriguing epidemiology literature of both P. falciparum and P. ...Continue Reading

References

Jan 1, 1979·Transactions of the Royal Society of Tropical Medicine and Hygiene·R S Bray, M J Anderson
Jul 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·F NostenN J White
Feb 1, 1990·Annals of Tropical Medicine and Parasitology·B J BrabinH J Van der Kaay
Feb 1, 1989·The American Journal of Tropical Medicine and Hygiene·E M RileyB M Greenwood
Feb 1, 1989·The American Journal of Tropical Medicine and Hygiene·S M HandunnettiK N Mendis
Mar 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·M P VleugelsR de Graaf
Aug 1, 1987·British Journal of Obstetrics and Gynaecology·M P VleugelsR de Graaf
Jan 1, 1985·Transactions of the Royal Society of Tropical Medicine and Hygiene·W A Krotoski
Jul 1, 1984·The American Journal of Tropical Medicine and Hygiene·I A McGregor
Jul 23, 1983·British Medical Journal·M Watkinson, D I Rushton
Nov 1, 1982·The American Journal of Tropical Medicine and Hygiene·W A KrotoskiP S Stanfill
Mar 1, 1980·The American Journal of Tropical Medicine and Hygiene·C C CampbellW E Collins
Mar 1, 1993·Histopathology·J N BulmerB M Greenwood
Nov 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·R UdomsanpetchN J White
Jan 1, 1996·The American Journal of Tropical Medicine and Hygiene·R W SteketeeJ G Breman
Mar 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·C LuxemburgerF Nosten
Nov 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·K MaitlandD K Bowden
May 1, 1997·Transactions of the Royal Society of Tropical Medicine and Hygiene·C LuxemburgerN J White
Oct 17, 1998·Parasite : Journal De La Société Française De Parasitologie·B MaubertP Deloron
Nov 6, 1998·Nature·M FriedP E Duffy
Aug 13, 1999·Bulletin of the World Health Organization·N SinghV P Sharma
Aug 18, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·J A SimpsonN J White
Aug 31, 1999·The American Journal of Tropical Medicine and Hygiene·I S SoaresM M Rodrigues
Sep 2, 1999·Lancet·F NostenN J White
Dec 22, 1999·Infection and Immunity·S J RogersonM E Molyneux
Jun 20, 2000·Lancet·S LindsayG Walraven
Aug 31, 2000·The New England Journal of Medicine·N DiagneJ F Trape
Mar 31, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·T SmithM P Alpers
Jun 27, 2001·The American Journal of Tropical Medicine and Hygiene·R W SteketeeC Menendez
Sep 5, 2001·American Journal of Epidemiology·C LuxemburgerF Nosten
Sep 15, 2001·Science·K FlickM Wahlgren
Aug 31, 2002·The American Journal of Tropical Medicine and Hygiene·J Alexandra RoweAhmed Raza
Feb 25, 2003·The Journal of Infectious Diseases·Samson M KinyanjuiKevin Marsh

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Citations

Oct 22, 2016·Cell·Alan F CowmanKevin Marsh
Dec 16, 2016·Expert Review of Anti-infective Therapy·Stephen J Rogerson, Holger W Unger
Oct 23, 2018·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Gideon Kofi HelegbeErnest Ofosu
Apr 2, 2019·Frontiers in Endocrinology·Johanna SeitzUdo Rudolf Markert
Mar 13, 2020·Clinical Microbiology Reviews·Johannes MischlingerMichael Ramharter
May 14, 2017·The American Journal of Tropical Medicine and Hygiene·Alistair R D McLeanFreya J I Fowkes

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Methods Mentioned

BETA
light microscopy
PCR

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