Malaria cases treated with artemether/lumefantrine in Japanese travelers

Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases
Satoshi KutsunaNorio Ohmagari

Abstract

Artemisinin-based combination therapy (ACT) has been the standard treatment for uncomplicated malaria. Although not licensed in Japan, artemether/lumefantrine (AL), one type of ACT, has been administered to patients with malaria since 2002 by the Research Group on Chemotherapy of Tropical Diseases. Herein, we reviewed malaria cases treated with AL in Japanese travelers. A retrospective study was conducted at the National Center for Global Health and Medicine from October 2005 to March 2013. There were 19 malaria patients treated with AL, and 10 falciparum malaria patients treated with AL only. In these 10 patients treated with AL only, the median time of fever clearance was 25.0 hours (range:14-66 hours), and the median time of parasite clearance was 36.0 hours (range:16-62 hours). There was a positive correlation between parasitemia and time from the start of therapy to the disappearance of the parasites. Parasitemia was higher (4.05% vs. 0.24%; p = 0.044) and parasite clearance time was longer (55.5 hours vs. 31.5 hours; p = 0.044) in the cases of recrudescence than non-recrudescence, respectively. Three of the 19 malaria patients showed recrudescence of malaria after treatment with AL. The reason that treatment failure was m...Continue Reading

References

Mar 12, 1999·Annual Review of Medicine·P Newton, N White
Feb 19, 2000·Antimicrobial Agents and Chemotherapy·F EzzetN J White
Dec 29, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·R BakshiE Alteri
May 3, 2003·Lancet·Alan M Spira
Oct 16, 2004·Expert Review of Anti-infective Therapy·Walther H Wernsdorfer
Nov 17, 2006·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Akihiro HitaniMikio Kimura
May 24, 2007·JAMA : the Journal of the American Medical Association·Grant DorseyPhilip J Rosenthal
Aug 24, 2007·PLoS Medicine·Nicholas M Anstey, Ric N Price
Mar 10, 2012·The American Journal of Tropical Medicine and Hygiene·Eran KopelEli Schwartz
Mar 21, 2012·Travel Medicine and Infectious Disease·Yasutaka MizunoTomohiko Takasaki
Sep 19, 2012·Malaria Journal·Helena H AsklingUNKNOWN European Society for Clinical Microbiology and Infectious Diseases Study Group on Clinical Parasitology

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Citations

Dec 15, 2020·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Satoshi KutsunaNorio Ohmagari

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