Malaria-derived hemozoin exerts early modulatory effects on the phenotype and maturation of human dendritic cells

Cellular Microbiology
Ioana BujilaAnn-Kristin Östlund Farrants

Abstract

Plasmodium falciparum (P. falciparum)-induced effects on the phenotype of human dendritic cells (DC) could contribute to poor induction of long-lasting protective immunity against malaria. DC ability to present antigens to naïve T cells, thus initiating adaptive immune responses depends on complex switches in chemokine receptors, production of soluble mediators and expression of molecules enabling antigen-presentation and maturation. To examine the cellular basis of these processes in the context of malaria, we performed detailed analysis of early events following exposure of human monocyte-derived DC to natural hemozoin (nHZ) and the synthetic analog of its heme core, β-hematin. DC exposed to either molecule produced high levels of the inflammatory chemokine MCP-1, showed continuous high expression of the inflammatory chemokine receptor CCR5, no upregulation of the lymphoid homing receptor CCR7 and no cytoskeletal actin redistribution with loss of podosomes. DC partially matured as indicated by increased expression of major histocompatibility complex (MHC) class II and CD86 following nHZ and β-hematin exposure, however there was a lack in expression of the maturation marker CD83 following nHZ but not β-hematin exposure. Overal...Continue Reading

References

Oct 1, 1998·European Journal of Immunology·F SallustoA Lanzavecchia
Jun 8, 1999·European Journal of Immunology·F SallustoA Lanzavecchia
Jun 3, 2000·Annual Review of Immunology·J BanchereauK Palucka
Apr 17, 2002·Cell·Yoko FujimotoThomas F Tedder
Jun 18, 2002·Infection and Immunity·Claudia BrodskynManoel Barral-Netto
Dec 24, 2003·Cell Motility and the Cytoskeleton·Siobhan BurnsAdrian J Thrasher
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sathit PichyangkulR Scott Miller
Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Oleksii A SkorokhodEvelin Schwarzer
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maritza JaramilloMartin Olivier
Jun 21, 2005·Cytokine & Growth Factor Reviews·Silvano Sozzani
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Suzanne F G van HeldenFrank N van Leeuwen
Feb 16, 2007·European Journal of Immunology·Cindy Aerts-ToegaertKarine Breckpot
Nov 16, 2007·Immunology Letters·Charlene M Prazma, Thomas F Tedder
May 29, 2008·Future Microbiology·Stephen M Todryk, Britta C Urban
Jun 20, 2008·Nature Immunology·Jean LanghorneKevin Marsh
Dec 18, 2008·The Journal of Infectious Diseases·Peter Gottfried KremsnerTerrie Taylor
Feb 12, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Juliette DiouMichel J Tremblay
Mar 3, 2010·Malaria Journal·Esther BettiolAna Rodriguez
Jul 20, 2010·Microbes and Infection·Marina T ShioMartin Olivier
Oct 26, 2010·Current Opinion in Immunology·Nancy M ChoiJeremy M Boss
Jul 10, 2013·The Journal of Experimental Medicine·Alberto Pinzon-CharryMichael F Good
Aug 3, 2013·BioFactors·Ariane TybergheinPhilippe E Van den Steen
Jan 16, 2014·Journal of Cell Science·Maksim V BaranovGeert van den Bogaart
Feb 20, 2014·Frontiers in Immunology·Martin OlivierSophie Fougeray
Feb 22, 2014·Biochimica Et Biophysica Acta·Lorena M CoronadoCarmenza Spadafora
Jul 16, 2014·Free Radical Biology & Medicine·Oleksii A SkorokhodEvelin Schwarzer
Oct 11, 2014·Cellular and Molecular Life Sciences : CMLS·Stefan Linder, Christiane Wiesner

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Citations

Apr 26, 2016·Journal of Immunology Research·Kelly N S AmorimSilvia B Boscardin
Jul 12, 2020·Scandinavian Journal of Immunology·Marita Troye-BlombergAnn-Kristin Östlund Farrants
Aug 5, 2017·Frontiers in Cellular and Infection Microbiology·Josefine DunstKai Matuschewski
Nov 22, 2019·Frontiers in Veterinary Science·Irina V SaltykovaPaul J Brindley
Jan 10, 2018·Immunity, Inflammation and Disease·Raquel A PinnaDalma M Banic
Aug 31, 2018·Frontiers in Immunology·Charles AramaOgobara K Doumbo
Dec 26, 2018·Frontiers in Immunology·Amaya Ortega-Pajares, Stephen J Rogerson
Nov 24, 2020·Trends in Parasitology·Thao-Thy PhamPhilippe E Van den Steen

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