Malaria genomics: tracking a diverse and evolving parasite population

International Health
Dominic Kwiatkowski

Abstract

Malaria parasites are continually evolving to evade the immune system and human attempts to control the disease. To eliminate malaria from regions where it is deeply entrenched we need ways of monitoring what is going on in the parasite population, detecting problematic changes as soon as they arise, and executing a prompt and effective response based on a deep understanding of this natural evolutionary process. Powerful new tools to address this problem are emerging from the fast-growing field of genomic epidemiology, driven by new sequencing technologies and computational methods that allow parasite genome variation to be studied in much greater detail and in many more samples than was previously considered possible. These new tools will provide a deep understanding of what is going on in the parasite population, generating actionable knowledge for strategic planning of control interventions, for monitoring their effects and steering them for greatest impact, and for raising the alert if things start to go wrong.

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Citations

Mar 4, 2015·International Health·Philip A Eckhoff, Andrew J Tatem
Jun 28, 2016·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Shruthi Sridhar VembarMelissa Laird Smith
Sep 9, 2016·Genome Medicine·Sebastian KirchnerAndrew P Waters
Nov 9, 2016·International Journal for Parasitology·Sarah Auburn, Alyssa E Barry
Sep 4, 2019·Malaria Journal·Sofonias K TessemaBryan Greenhouse
Aug 26, 2020·The Journal of Infectious Diseases·Sofonias K TessemaBryan Greenhouse
Aug 29, 2018·Nature Microbiology·W Robert Shaw, Flaminia Catteruccia
Dec 21, 2019·International Journal for Parasitology·Larissa CalarcoJohn Ellis

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