Malaria in pregnancy shapes the development of foetal and infant immunity

Parasite Immunology
Whitney E HarringtonPrasanna Jagannathan

Abstract

Malaria, particularly Plasmodium falciparum, continues to disproportionately affect pregnant women. In addition to the profoundly deleterious impact of maternal malaria on the health of the mother and foetus, malaria infection in pregnancy has been shown to affect the development of the foetal and infant immune system and may alter the risk of malaria and nonmalarial outcomes during infancy. This review summarizes our current understanding of how malaria infection in pregnancy shapes the protective components of the maternal immune system transferred to the foetus and how foetal exposure to parasite antigens impacts the development of foetal and infant immunity. It also reviews existing evidence linking malaria infection in pregnancy to malaria and nonmalarial outcomes in infancy and how preventing malaria in pregnancy may alter these outcomes. A better understanding of the consequences of malaria infection in pregnancy on the development of foetal and infant immunity will inform control strategies, including intermittent preventive treatment in pregnancy and vaccine development.

Associated Clinical Trials

Jun 8, 2016·Grant Dorsey, M.D, Ph.D., Grant Dorsey, M.D, Ph.D.

References

Jan 1, 1992·Annals of Tropical Paediatrics·B Brabin
Sep 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·A M GreenwoodB M Greenwood
Mar 1, 1994·The Journal of Infectious Diseases·F NostenN J White
Jan 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P NyirjesyP R Fischer
Jan 1, 1996·Archives of Disease in Childhood. Fetal and Neonatal Edition·T J O'DempseyB M Greenwood
Jan 1, 1996·The American Journal of Tropical Medicine and Hygiene·J M McDermottD L Heymann
Jan 1, 1996·The American Journal of Tropical Medicine and Hygiene·R W SteketeeC C Campbell
Oct 1, 1996·Parasite Immunology·N FievetP Deloron
Nov 6, 1998·Nature·M FriedP E Duffy
Apr 9, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·M I de Moraes-PintoC A Hart
Jun 27, 2001·The American Journal of Tropical Medicine and Hygiene·R W SteketeeC Menendez
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christopher L KingJames W Kazura
Jan 31, 2002·Transactions of the Royal Society of Tropical Medicine and Hygiene·H L Guyatt, R W Snow
Jul 10, 2003·Vaccine·Neil E Simister
Aug 22, 2003·Clinical and Experimental Immunology·J IsmailiM Pinder
Apr 15, 2004·Placenta·B J BrabinJ Ordi
Jun 10, 2004·Annals of Tropical Paediatrics·Francine H VerhoeffBernard J Brabin
Jun 18, 2004·Emerging Infectious Diseases·John G AyisiBernard L Nahlen
Jan 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kim BrustoskiUrszula Krzych
Apr 20, 2005·The Journal of Infectious Diseases·Ilka EngelmannAdrian J F Luty
Apr 21, 2005·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Eric A AchidiMarita Troye-Blomberg
Nov 2, 2005·PLoS Medicine·Theonest K MutabingwaPatrick E Duffy
May 23, 2006·Archives of Disease in Childhood·S OwensB J Brabin
Sep 22, 2006·Infection and Immunity·Lutz P BreitlingAdrian J F Luty
Nov 4, 2006·Molecular and Biochemical Parasitology·Kelly BroenAdrian J F Luty
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arlene DentChristopher L King
Nov 16, 2006·PLoS Medicine·Atis MuehlenbachsPatrick E Duffy
Jan 26, 2007·The Lancet Infectious Diseases·Stephen J RogersonDiane W Taylor
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simon MetenouDiane Wallace Taylor

❮ Previous
Next ❯

Citations

Feb 26, 2019·Parasite Immunology·William Horsnell, Benjamin Dewals
Apr 12, 2019·Parasite Immunology·Ann M MoormannCatherine S Forconi
Sep 26, 2019·Immunological Reviews·Margaret E Feeney
Aug 12, 2020·Journal of Cellular and Molecular Medicine·Lilian M MartinelliEnrrico Bloise
Nov 21, 2018·BMC Medicine·Prasanna Jagannathan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.