Malaria proteomics: insights into the parasite-host interactions in the pathogenic space

Journal of Proteomics
José M BautistaAntonio Puyet

Abstract

Proteomics is improving malaria research by providing global information on relevant protein sets from the parasite and the host in connection with its cellular structures and specific functions. In the last decade, reports have described biologically significant elements in the proteome of Plasmodium, which are selectively targeted and quantified, allowing for sensitive and high-throughput comparisons. The identification of molecules by which the parasite and the host react during the malaria infection is crucial to the understanding of the underlying pathogenic mechanisms. Hence, proteomics is playing a major role by defining the elements within the pathogenic space between both organisms that change across the parasite life cycle in association with the host transformation and response. Proteomics has identified post-translational modifications in the parasite and the host that are discussed in terms of functional interactions in malaria parasitism. Furthermore, the contribution of proteomics to the investigation of immunogens for potential vaccine candidates is summarized. The malaria-specific technological advances in proteomics are particularly suited now for identifying host-parasite interactions that could lead to promi...Continue Reading

References

Mar 1, 1987·Molecular and Biochemical Parasitology·C PinswasdiK Pavanand
Feb 8, 2002·Nature·Thomas L Richie, Allan Saul
Apr 4, 2002·The Journal of Infectious Diseases·Stephen L HoffmanThomas L Richie
Oct 9, 2002·Nature·Malcolm J GardnerBart Barrell
Oct 9, 2002·Nature·Laurence FlorensDaniel J Carucci
Oct 9, 2002·Nature·Malcolm J GardnerClaire M Fraser
Mar 14, 2003·Nature·Ruedi Aebersold, Matthias Mann
Jul 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Denise L DoolanAlessandro Sette
Aug 2, 2003·Science·Karine G Le RochElizabeth A Winzeler
Nov 25, 1961·Nature·S COHENS CARRINGTON
Sep 25, 2003·The Journal of Experimental Biology·D L DoolanD J Carucci
Mar 24, 2004·International Journal for Parasitology·Katja BeckerHagai Ginsburg
Aug 4, 2004·Molecular and Biochemical Parasitology·Laurence FlorensYimin Wu
Oct 12, 2004·Journal of Proteome Research·Tobili Y Sam-YelloweJohn R Yates
Nov 3, 2004·The Journal of Experimental Medicine·Ali SalantiThor G Theander
Nov 16, 2004·Methods : a Companion to Methods in Enzymology·Anne S De Groot, Jay A Berzofsky
Jan 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·D Huw DaviesPhilip L Felgner
Mar 2, 2005·Nature Reviews. Molecular Cell Biology·H Jane Dyson, Peter E Wright
Mar 19, 2005·Immunity·Alessandro SetteStephen Wilson
Apr 16, 2005·Proteomics·Michael MakangaStephen A Ward
Sep 3, 2005·Trends in Parasitology·Geoffrey A Targett
Sep 3, 2005·Nature Reviews. Immunology·Louis Schofield, Georges E Grau
Oct 6, 2005·The Journal of Biological Chemistry·Paul R SandersBrendan S Crabb
Nov 29, 2005·Transactions of the Royal Society of Tropical Medicine and Hygiene·Franck RemoueFrançois Simondon
Feb 1, 2006·Expert Review of Proteomics·Paul F G Sims, John E Hyde
Feb 25, 2006·Cell·Alan F Cowman, Brendan S Crabb

❮ Previous
Next ❯

Citations

Feb 2, 2016·Developmental and Comparative Immunology·Ariadna Sitjà-BobadillaJaume Pérez-Sánchez
Dec 30, 2014·Journal of Proteomics·D C AndersonMary R Galinski
Jul 15, 2015·Proteomics. Clinical Applications·Allison C Galassie, Andrew J Link
Dec 3, 2014·Current Opinion in Chemical Biology·Edward W TateEmmanuelle Thinon
Feb 24, 2018·Frontiers in Cellular and Infection Microbiology·Catarina BourgardFabio T M Costa
Jun 17, 2020·Database : the Journal of Biological Databases and Curation·Ankita SinghB Jayaram
May 16, 2015·Asian Pacific Journal of Tropical Medicine·Vivek Bhakta Mathema, Kesara Na-Bangchang
Mar 27, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Min ZhouThomas Efferth
Jun 1, 2021·Frontiers in Cellular and Infection Microbiology·Richard Thomson-Luque, José M Bautista

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Antigenic Modulation

Antigenic modulation occurs when an antibody cross-links antigens on a cell surface, causing the antigens to become internalized. This can lead to therapeutic failure of monoclonal antibodies as the expression of the antigen becomes decreased on target cells. Find the latest research on antigenic modulation here.

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

Cell Cycle Control & Proteolysis

Key regulators of cell cycle, including cyclins, cyclin dependent kinase inhibitors, DNA replication factors, are controlled by proteolysis. Discover the latest research on cell cycle control and proteolysis.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

© 2022 Meta ULC. All rights reserved