Malaria transmission-blocking drugs: implications and future perspectives.

Future Medicinal Chemistry
Ishan WadiAbhinav Sinha

Abstract

As the world gets closer to eliminating malaria, the scientific community worldwide has begun to realize the importance of malaria transmission-blocking interventions. The onus of breaking the life cycle of the human malaria parasite Plasmodium falciparum predominantly rests upon transmission-blocking drugs because of emerging resistance to commonly used schizonticides and insecticides. This third part of our review series on malaria transmission-blocking entails transmission-blocking potential of preclinical transmission-blocking antimalarials and other non-malaria drugs/experimental compounds that are not in clinical or preclinical development for malaria but possess transmission-blocking potential. Collective analysis of the structure and the activity of these experimental compounds might pave the way toward generation of novel prototypes of next-generation transmission-blocking drugs.

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Citations

Mar 5, 2022·Expert Opinion on Therapeutic Patents·Sara ConsalviGiovanna Poce

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Methods Mentioned

BETA
dissection
MDA

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