Malaria transmission, infection, and disease at three sites with varied transmission intensity in Uganda: implications for malaria control

The American Journal of Tropical Medicine and Hygiene
Moses R KamyaGrant Dorsey

Abstract

The intensification of control interventions has led to marked reductions in malaria burden in some settings, but not others. To provide a comprehensive description of malaria epidemiology in Uganda, we conducted surveillance studies over 24 months in 100 houses randomly selected from each of three subcounties: Walukuba (peri-urban), Kihihi (rural), and Nagongera (rural). Annual entomological inoculation rate (aEIR) was estimated from monthly Centers for Disease Control and Prevention (CDC) light trap mosquito collections. Children aged 0.5-10 years were provided long-lasting insecticidal nets (LLINs) and followed for measures of parasite prevalence, anemia and malaria incidence. Estimates of aEIR were 2.8, 32.0, and 310 infectious bites per year, and estimates of parasite prevalence 7.4%, 9.3%, and 28.7% for Walukuba, Kihihi, and Nagongera, respectively. Over the 2-year study, malaria incidence per person-years decreased in Walukuba (0.51 versus 0.31, P = 0.001) and increased in Kihihi (0.97 versus 1.93, P < 0.001) and Nagongera (2.33 versus 3.30, P < 0.001). Of 2,582 episodes of malaria, only 8 (0.3%) met criteria for severe disease. The prevalence of anemia was low and not associated with transmission intensity. In our cohor...Continue Reading

References

Mar 16, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·J A KurtzhalsL Hviid
Jan 1, 1991·Parasitology Today·B GreenwoodR Snow
Aug 16, 2006·Malaria Journal·Claudia FreyOlaf Müller
May 24, 2007·JAMA : the Journal of the American Medical Association·Grant DorseyPhilip J Rosenthal
Nov 17, 2007·Malaria Journal·Emelda A OkiroRobert W Snow
Mar 24, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·Urvashi RamphulPie Müller
Sep 12, 2009·Trends in Parasitology·David L SmithRobert W Snow
Oct 10, 2009·The American Journal of Tropical Medicine and Hygiene·Hasifa BukirwaGrant Dorsey
Feb 12, 2011·PLoS Medicine·UNKNOWN malERA Consultative Group on Monitoring, Evaluation, and Surveillance
Dec 22, 2011·Malaria Journal·Peter W GethingSimon I Hay
Feb 7, 2012·Emerging Infectious Diseases·Arantxa Roca-FeltrerRobert S Heyderman
Feb 7, 2012·Lancet·Christopher J L MurrayAlan D Lopez
Nov 14, 2012·Parasites & Vectors·Hans J OvergaardMichel A Slotman
Feb 1, 2014·Advances in Parasitology·Lucy S TustingChris Drakeley

❮ Previous
Next ❯

Citations

Jan 30, 2016·Transactions of the Royal Society of Tropical Medicine and Hygiene·Oliver J BradyDavid L Smith
Dec 17, 2015·The Journal of Infectious Diseases·Lila A FarringtonMargaret E Feeney
Jul 29, 2015·Proceedings of the National Academy of Sciences of the United States of America·Danica A HelbBryan Greenhouse
Sep 30, 2015·Malaria Journal·Simon P KigoziAndrew J Tatem
Aug 31, 2016·Frontiers in Public Health·Guofa ZhouGuiyun Yan
Dec 3, 2016·Nucleic Acids Research·Cristina AurrecoecheaJie Zheng
Mar 18, 2015·The American Journal of Tropical Medicine and Hygiene·Steven R Meshnick
Jan 27, 2016·The American Journal of Tropical Medicine and Hygiene·Lucy S TustingSteve W Lindsay
Dec 28, 2017·The American Journal of Tropical Medicine and Hygiene·Ross BoyceMark J Siedner
Mar 17, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rada M SavicFrancesca T Aweeka
Jul 1, 2017·BMC Medicine·Polycarp MogeniUNKNOWN Hotspot Group Authors
Oct 11, 2017·The American Journal of Tropical Medicine and Hygiene·Melissa D ConradPhilip J Rosenthal
Aug 22, 2018·ELife·Michael White, James Watson
Oct 10, 2018·The American Journal of Tropical Medicine and Hygiene·Bryan GreenhouseChris J Drakeley
Oct 11, 2017·The American Journal of Tropical Medicine and Hygiene·Shereen KatrakBryan Greenhouse
Jun 6, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Emmanuel ArinaitweSarah G Staedke
Feb 7, 2018·Malaria Journal·Shereen KatrakBryan Greenhouse
Jan 11, 2019·The American Journal of Tropical Medicine and Hygiene·Andrea L ConroyChandy C John
May 30, 2019·Transactions of the Royal Society of Tropical Medicine and Hygiene·Yang Jae LeeMerlin Willcox
May 11, 2019·The American Journal of Tropical Medicine and Hygiene·Simon P KigoziRachel L Pullan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

BioHub - Researcher Network

The Chan-Zuckerberg Biohub aims to support the fundamental research and develop the technologies that will enable physicians to cure, prevent, or manage all diseases in our childrens' lifetimes. The CZ Biohub brings together researchers from UC Berkeley, Stanford, and UCSF. Find the latest research from the CZ Biohub researcher network here.