Malaria Vaccines: Recent Advances and New Horizons.

Cell Host & Microbe
Simon J DraperRobert A Seder

Abstract

The development of highly effective and durable vaccines against the human malaria parasites Plasmodium falciparum and P. vivax remains a key priority. Decades of endeavor have taught that achieving this goal will be challenging; however, recent innovation in malaria vaccine research and a diverse pipeline of novel vaccine candidates for clinical assessment provides optimism. With first-generation pre-erythrocytic vaccines aiming for licensure in the coming years, it is important to reflect on how next-generation approaches can improve on their success. Here we review the latest vaccine approaches that seek to prevent malaria infection, disease, and transmission and highlight some of the major underlying immunological and molecular mechanisms of protection. The synthesis of rational antigen selection, immunogen design, and immunization strategies to induce quantitatively and qualitatively improved immune effector mechanisms offers promise for achieving sustained high-level protection.

Citations

Oct 6, 2018·The Journal of Biological Chemistry·Nicole KilianChoukri Ben Mamoun
Jan 3, 2019·Expert Review of Vaccines·K L WilsonM Plebanski
Jan 11, 2019·The American Journal of Tropical Medicine and Hygiene·Philip J RosenthalN Regina Rabinovich
Mar 16, 2019·Scientific Reports·Anne-Marie C AnderssonMark Howarth
Apr 12, 2019·Parasite Immunology·Ann M MoormannCatherine S Forconi
Sep 24, 2019·Human Vaccines & Immunotherapeutics·Matthew B Laurens
Oct 15, 2019·Immunological Reviews·Claire LoiseauDenise L Doolan
Oct 24, 2019·Immunological Reviews·Lis R AntonelliRicardo T Gazzinelli
Jan 17, 2020·Molecular Informatics·Subrata PramanikKlaus Heese
Apr 29, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Nicole KilianAndreas M Ernst
May 15, 2020·Science Translational Medicine·Gemma MoncunillCarlota Dobaño
Aug 30, 2019·Nature Reviews. Immunology·Jean-Philippe Julien, Hedda Wardemann
Sep 2, 2020·Molecular Biotechnology·Evelia M Milán-NorisSchuyler S Korban
Feb 9, 2019·Expert Review of Vaccines·Martha M CooperDenise L Doolan
Jan 5, 2020·Virulence·Allison N Bucşan, Kim C Williamson
May 14, 2020·F1000Research·Nirianne Marie Q Palacpac, Toshihiro Horii
Oct 10, 2018·Nature Nanotechnology·Robert S Oakes, Christopher M Jewell
Sep 24, 2019·Human Vaccines & Immunotherapeutics· SunitaPratyoosh Shukla
Dec 13, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Brian Gitta, Nicole Kilian
Oct 1, 2019·SAR and QSAR in Environmental Research·J Devillers, H Devillers
Feb 21, 2019·Advanced Functional Materials·Caroline MorrisAndrew D Davidson
Jul 29, 2020·Frontiers in Microbiology·Lampouguin Yenkoidiok-DoutiCarolina Barillas-Mury
Dec 21, 2018·Parasite Immunology·Eleanor M Riley, Richard K Grencis
Apr 4, 2019·Nature Reviews. Immunology·Samarchith P KurupJohn T Harty
Jan 31, 2020·Malaria Journal·Denis DelicMarcos J Araúzo-Bravo
Jan 9, 2019·Frontiers in Immunology·Leslie S ItsaraAnil K Ghosh
Mar 17, 2020·Frontiers in Immunology·Catherine J Mitran, Stephanie K Yanow
Jun 20, 2019·Frontiers in Immunology·Joseph J IllingworthSimon J Draper
Nov 27, 2020·Microbiology and Molecular Biology Reviews : MMBR·Gunnar Lindahl
Nov 21, 2020·ChemMedChem·Mélanie FonteCátia Teixeira
Dec 17, 2020·Wiener klinische Wochenschrift·Meinolf EbbersEmil C Reisinger

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
ELISA

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

© 2022 Meta ULC. All rights reserved