Malarial parasites vs. antimalarials: never-ending rumble in the jungle

Current Molecular Medicine
Benjamin Mordmüller, Peter G Kremsner

Abstract

Development of resistance is an increasing problem for antimalarial chemotherapy because resistance against most available drugs has developed in the majority of world-wide parasite populations. Therefore, several strategies to counteract resistance-development are in place. From the pharmaceutical side, identification of new targets and compounds, development of structural relatives of known antimalarials, and fixed combination therapy are pursued. On the other hand, clinical studies focus on novel regimens, distribution schemes and drug combinations. A third possibility to diminish progression of resistance is the application of evolutionary concepts to design new strategies for validation, monitoring and interference with the selection-process that leads to the spread of multidrug-resistance. Since the pharmacologic and clinical side of antimalarial chemotherapy is covered by recent reviews we refer to the newest developments only and lay our focus on determinants of selection for drug resistance in human malaria.

Citations

Apr 19, 2008·The New England Journal of Medicine·Kodjo AyiKevin C Kain
May 22, 2013·Antimicrobial Agents and Chemotherapy·Serena TschanBenjamin Mordmüller
Oct 21, 2009·Antimicrobial Agents and Chemotherapy·Jana HeldBenjamin Mordmüller
Mar 21, 2007·Antimicrobial Agents and Chemotherapy·Jacob D JohnsonNorman C Waters
Apr 14, 2010·Wiener klinische Wochenschrift·Benjamin Mordmüller
Oct 5, 2013·Expert Opinion on Drug Discovery·Jana HeldBenjamin Mordmüller
Aug 1, 2015·Future Microbiology·Jose Francisco FernandesMartin Peter Grobusch
Mar 17, 2010·International Journal of Antimicrobial Agents·Jana HeldBenjamin Mordmüller
Feb 2, 2011·Expert Opinion on Therapeutic Targets·Serena TschanJürgen F J Kun
Jun 27, 2012·Journal of Medicinal Chemistry·Karin BrücherThomas Kurz

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