MALAT1 modulates the autophagy of retinoblastoma cell through miR-124-mediated stx17 regulation

Journal of Cellular Biochemistry
Jun HuangKe Liu

Abstract

The retinoblastoma is the most common intraocular malignant tumor in infants and children; it is one of the deadliest forms of cancer due to its limited sensitivity to chemotherapy and radiotherapy. In several cancers, chemoresistance is associated with autophagy induction. Non-coding RNAs, including long non-coding RNAs (lncRNA) and microRNAs (miRNAs) have been reported to regulate physiological activities of the cells, including proliferation, apoptosis, migration, as well as autophagy. MALAT1, a well-established lncRNA acts as an oncogene, promotes cancer proliferation, and metastasis via the stimulation of autophagy. In addition to MALAT1, miR-124, a known tumor suppressor, has also been reported to regulate cell apoptosis and autophagy in dopaminergic neurons. In the present study, we investigated the roles of MALAT1 and miR-124 in the regulation of retinoblastoma cell autophagy through evaluating the changes of autophagy-related proteins. Through direct targeting miR-124, MALAT1 promotes retinoblastoma cell autophagy. Further, we investigated whether Syntaxin 17 (STX17), a Soluble NSF Attachment Protein receptor (SNARE) of the autophagosome, is involved in MALAT1/miR-124 regulation of retinoblastoma cell autophagy, and th...Continue Reading

References

Feb 29, 2008·Nature·Noboru MizushimaDaniel J Klionsky
Feb 10, 2009·Methods in Enzymology·Chantal BauvyPatrice Codogno
Aug 6, 2009·Annual Review of Genetics·Congcong He, Daniel J Klionsky
Mar 2, 2010·Cancer Biotherapy & Radiopharmaceuticals·Jing-Hua RenGang Wu
Jul 1, 2010·Expert Review of Neurotherapeutics·Paula I MoreiraGeorge Perry
Oct 23, 2010·Molecular Cell·Guido KroemerBeth Levine
Apr 15, 2011·Molecular Cancer·Ewan A GibbWan L Lam
Jun 7, 2011·Cell Metabolism·Daolin TangMichael T Lotze
Mar 15, 2012·Lancet·Helen DimarasBrenda L Gallie
Aug 21, 2012·Carcinogenesis·Lisa B Frankel, Anders H Lund
Sep 18, 2012·Cell Cycle·Ravi K Amaravadi
Mar 1, 2013·Nature·Thomas B HansenJørgen Kjems
Mar 5, 2013·Nature·Maho HamasakiTamotsu Yoshimori
Mar 8, 2013·Autophagy·Eisuke Itakura, Noboru Mizushima
Mar 27, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Tony GutschnerSven Diederichs
Jun 28, 2014·PloS One·Shuo GengChenglin Yang
Oct 18, 2014·Molecular Medicine Reports·Lingjie BaoXiaofang Yi
Aug 6, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shikai LiuLiang Zhang
Aug 16, 2016·Biochemical and Biophysical Research Communications·Peng YuanJianghe Fan
Dec 16, 2016·International Journal of Molecular Sciences·Armin ZebischHeinz Sill
Mar 10, 2017·Genes·Duncan Ayers, Jo Vandesompele
Mar 16, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Li-Juan LiLian-Sheng Zhang

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Citations

Jul 22, 2018·Journal of Cellular and Molecular Medicine·Ge YangQiuming Li
Oct 17, 2018·Journal of Cellular and Molecular Medicine·Hengwei LiuXingao Xiong
Feb 19, 2019·Wiley Interdisciplinary Reviews. RNA·Patricia P ColtriGuilherme H G da Silva
Jan 28, 2020·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Hao HuLikun Ma
Oct 12, 2018·Journal of Biochemistry·Fengqian ShenLing Gao
Oct 24, 2018·Journal of Cancer Research and Clinical Oncology·Lara Elis Alberici DelsinMaria Sol Brassesco
Sep 11, 2020·Cardiovascular Diabetology·Karima Ait-AissaModar Kassan
May 19, 2019·Cell Death & Disease·Fei LiXiaogang Wang
Jan 30, 2019·Frontiers in Genetics·Md Zahirul Islam KhanHelen Ka Wai Law
Jan 8, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Soudeh Ghafouri-FardMohammad Taheri
Dec 15, 2020·European Journal of Pharmacology·Milad AshrafizadehMasoud Najafi
Feb 3, 2021·Autophagy·Soudeh Ghafouri-FardMohammad Taheri
Apr 4, 2021·Diagnostics·Francesca GattoFrancesca Nazio
Aug 17, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chunmei HuChunling Xu
Apr 5, 2021·Experimental Eye Research·Jinlu Liu, Xiaohan Qu
Jul 17, 2021·Oncology Letters·Teng WanShouhong Zhou
Aug 14, 2021·Acta Pharmaceutica Sinica. B·Javad MasoumiHamid Reza Mirzaei
Feb 24, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xue-Zhi WuLei Feng

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