Malaysian Indians are genetically similar to Caucasians: CYP2C9 polymorphism

Journal of Clinical Pharmacy and Therapeutics
Z ZainuddinR Ismail

Abstract

CYP2C9 is one of the major drug metabolizing enzymes for many drugs including warfarin, NSAIDs and losartan. It is polymorphic in many populations. Data on the distribution of CYP2C9 and the implication of CYP2C9 polymorphism in the Malaysian population is lacking. Our objectives were therefore to investigate the prevalence of CYP2C9 variants among unrelated healthy volunteers of Malays, Chinese and Indians in Malaysia. Deoxyribonucleic acid was extracted using standard lysis methods. Allele specific polymerase chain reaction was performed for determination of CYP2C9*1, *2, *3, *4 and *5 variants according to Z. Zainuddin, L.K. Teh, A.W.M. Suhaimi, M.Z. Salleh, R. Ismail (2003, Clinica Chimica Acta, 336, 97). The Chinese had the highest frequency of CYP2C9*1 (321/330, 97.27%), followed by the Malays and the Indians (402 of 420, 95.71% and 291 of 330, 88.18%, respectively). CYP2C9*2 was not found in the Chinese. CYP2C9*3 were detected in all the three races with the Indians having the highest frequency of CYP2C9*3 (9.7%). The Indians had a frequency of CYP2C9*2 and *3 similar to Tamilians and Caucasians. Two of the Indians had *2/*3 and one had *3/*3 genotypes and are likely to be slow metabolizers. No subject with CYP2C9*4 and ...Continue Reading

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Citations

Jan 10, 2013·Journal of Postgraduate Medicine·N MusaR Ismail
Nov 26, 2015·Expert Opinion on Drug Metabolism & Toxicology·Carolina Céspedes-GarroAdrián LLerena
Jun 24, 2008·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·H NgowM Z Salleh
Apr 16, 2013·BioMed Research International·Abdullah M AlzahraniVangelis G Manolopoulos
Jan 9, 2019·Environmental Science and Pollution Research International·Kaixuan ZhangXiangyu Xu
Oct 29, 2013·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·Z CavdarG A Guner

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