Male-associated hypertension in LDL-R deficient mice

Biochemical and Biophysical Research Communications
V N Trieu, F M Uckun

Abstract

Hypertension is more common among African Americans than Americans of European descent. However, the genetic etiology has not been defined. Similarly, lipoprotein (Lp) (a), an independent risk factor for cardiovascular disease, is higher among African Americans. To explore the relationship between Lp (a) and hypertension, we measured the blood pressure of transgenic mice expressing apolipoprotein(a), the unique protein moiety of lipoprotein(a). As controls, we also determined blood pressure for apoE deficient mice, low density lipoprotein-receptor (LDL-R) deficient mice, and wild type C57Bl/6 mice. Apo(a) expression was not associated with hypertension. Surprisingly, LDL-R deficient mice exhibited male-associated hypertension. This observation could explain the higher incidence of atherosclerosis in male LDL-R deficient mice and human familial hypercholesterolemia (FH) patients. LDL-R deficient mice were more sensitive to photochemically induced cerebral stroke. However, this hypersensitivity was only modestly associated with sexual dimorphism. The presented data suggest that LDL-R deficiency results in hitherto unrecognized changes in the vascular tone.

References

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Citations

Mar 16, 2012·Biology of Sex Differences·Kathryn Sandberg, Hong Ji
Dec 15, 2000·Kidney International·O SmithiesM H Edgell
Aug 20, 2010·Autonomic Neuroscience : Basic & Clinical·Juliano S EvangelhoKatya Rigatto
Apr 25, 2008·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Cristina CamposKatya Rigatto
Jul 3, 2013·Hypertension·Matthew J HoffmanCarol Moreno
Nov 13, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·R YangH Jin
Jun 6, 2003·Endocrine Reviews·Peter Y LiuDavid J Handelsman
Apr 8, 2006·Physiological Reviews·Linda J MullinsJohn J Mullins

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