Male carriers of balanced reciprocal translocations in Northeast China: sperm count, reproductive performance, and genetic counseling

Genetics and Molecular Research : GMR
H-G ZhangR-Z Liu

Abstract

Balanced chromosomal translocations in men can cause failure of spermatogenesis owing to meiotic impairment. Male carriers may exhibit normozoospermia, although clinical manifestations can include oligozoospermia or azoospermia, oligozoospermia or normozoospermia. Here, we reported the characteristics of balanced reciprocal translocations in men from northeastern China, and explored the relationship between sperm count and reproductive performance, to enable informed genetic counseling. The frequency of balanced reciprocal translocations was found to be 1.62%. Semen analysis showed that 5.9% of male carriers had azoospermia, 43.1% had oligozoospermia, and 51.0% had normozoospermia. Of the 25 men with a balanced reciprocal translocation and azoospermia or oligozoospermia, chromosome 1 was the most commonly often involved in the translocation. However, in the 26 normozoospermic men with a balanced reciprocal translocation and normozoospermia, chromosome 3 was most commonly implicated. Fifty percent of men with a balanced reciprocal translocation conceived a pregnancy that went to term. Our data suggest that of all chromosomes, chromosomes 1 and 3 are the most commonly involved chromosomes in balanced reciprocal such translocation...Continue Reading

Citations

Aug 25, 2017·The Journal of International Medical Research·Yuan PanRui-Zhi Liu
Dec 9, 2017·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Xinyue ZhangRuizhi Liu
Nov 14, 2018·Journal of Assisted Reproduction and Genetics·Hadar AmirDalit Ben-Yosef
Apr 22, 2016·Molecular Cytogenetics·Hong Yan LiuYing Tai Wang
Nov 19, 2019·Open Medicine·Ruixue WangHongguo Zhang
Nov 25, 2020·Journal of Assisted Reproduction and Genetics·Caixia LeiXiaoxi Sun
Dec 24, 2019·American Journal of Human Genetics·Samantha L P SchilitCynthia C Morton
Dec 7, 2018·Reproductive Biomedicine Online·Anne MayeurNelly Frydman

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